Renoprotective role of Lipocalin-2 in allograft rejection following kidney transplantation (C02)

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Using a mouse model of kidney transplantation, we recently demonstrated a renoprotective role of exogenously administered recombinant Lcn2:Siderophore:Fe complex (rLcn2) during the early phase of allograft rejection. In this project, we aim at (I) understanding the route and mechanisms of immunoregulation and/or cytoprotection, mediated by the exogenousrLcn2; and (II) characterizing the source and nature of endogenous Lipocalin-2 i.e. whether it is complexed with mammalian iron binding catechols and may contribute to allograft survival in the long run. Our ultimate goal is to pave the way for transplant renoprotection via recombinant Lipocalin-2.