PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
PQ6:Lipocalin-2 作为预防癌症恶病质的治疗靶点
基本信息
- 批准号:10152268
- 负责人:
- 金额:$ 39.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdipose tissueAgonistAmplifiersAnimalsAnorexiaAttenuatedAutomobile DrivingBacterial InfectionsBehaviorBehavioralBlood - brain barrier anatomyBody Weight decreasedBone MarrowBrainCachexiaCancer PatientCellsChronicChronic DiseaseCollaborationsDataDesire for foodDevelopmentDiseaseEncephalitisEndocrineEndotheliumEventEvolutionFatigueGoalsGrowthHippocampus (Brain)Hypothalamic structureImmuneImpaired cognitionIn VitroInflammationInflammatoryInflammatory ResponseInjuryInterventionIronLCN2 geneLaboratoriesLethargiesLifeMalignant NeoplasmsMelanocortin 4 ReceptorMetabolicMetabolismMorbidity - disease rateMotivationMuscleMuscular AtrophyMyeloid CellsNeuraxisNeurocognitiveNeurocognitive DeficitNeuroendocrinologyNeurologicNeuronsPancreatic Ductal AdenocarcinomaPathogenesisPathologicPathologyPathway interactionsPatientsPeripheralPharmacologic SubstancePhysiologicalPlayPopulationPreventionProcessProductionProteinsPublicationsQuality of lifeReagentResearchResearch DesignRoleSavingsSeriesSick RoleSignal PathwaySignal TransductionSterilityStrokeSympathetic Nervous SystemSymptomsSystemic diseaseTestingTherapeutic InterventionTissuesToxic effectappetite losscancer cachexiacancer preventioncancer therapycancer typecell transformationdesigndrug developmentin vivomortality riskmotivated behaviormouse modelneural circuitneuroinflammationneurotoxicneurotoxicitynew therapeutic targetnovelnutritionpathogenrecruitresilienceresponsesensortherapeutic targettherapeutically effectivetumortumor growth
项目摘要
Project Summary:
Illness behaviors, metabolic disturbances, and cognitive decline are common in patients with chronic systemic
diseases, and contribute substantially to quality of life and ultimate survival. Other illness-induced morbidities
including anorexia and lethargy also compromise the ability of patients to recover from life-saving or extending
interventions, and diminish the motivational drive to aggressively battle the underlying condition. Although
cachexia in cancer patients was described more than two thousand years ago, the central mechanisms
underlying this disorder are poorly understood. Furthermore, there is currently no effective pharmaceutical
treatment. Cognitive decline is common in all chronic diseases, and can be a presenting complaint in cancer
patients, even prior to initiation of therapy. Our laboratory is dedicated to unraveling the basic mechanisms
whereby cancer triggers neuroinflammation, a key driver of cachexia and cognitive decline in patients with
cancer. In this proposal, we will focus on understanding the scope and mechanism by which systemic illness
induces the production of a molecule called lipocalin-2, that in turn acts on the brain to cause loss of appetite
and cognitive decline. The significance of this proposal resides in its unique combination of our historical focus
on neuroendocrinology and neuroinflammation, with new collaborations and efforts directed at understanding
the extent and mechanisms of anorexia and neurocognitive decline in patients with cancer. The long-term goal
of our research is to gain mechanistic understanding of the acute illness response and how it is transitioned
into chronic neuroinflammation in all cancer types, in order to develop more effective therapeutic interventions.
项目摘要:
疾病行为、代谢紊乱和认知能力下降在慢性全身性疾病患者中很常见。
疾病,并大大有助于生活质量和最终生存。其他疾病引起的发病率
包括厌食和嗜睡也损害了病人从挽救生命或延长生命中恢复的能力。
干预,并减少积极与潜在疾病作斗争的动机。虽然
癌症患者的恶病质早在两千多年前就有描述,
对这种疾病的潜在原因知之甚少。此外,目前还没有有效的药物
治疗认知能力下降在所有慢性疾病中很常见,也可能是癌症的一个症状
患者,甚至在开始治疗之前。我们的实验室致力于揭示
由此癌症触发神经炎症,这是恶病质和认知能力下降患者的关键驱动因素。
癌在本提案中,我们将重点关注了解系统性疾病的范围和机制,
诱导一种叫做脂质运载蛋白-2的分子的产生,这种分子反过来作用于大脑,导致食欲不振
和认知能力下降这项建议的意义在于它独特地结合了我们的历史重点,
在神经内分泌学和神经炎症,与新的合作和努力,旨在了解
癌症患者厌食和神经认知能力下降的程度和机制。远景目标
我们的研究的一个目的是获得对急性疾病反应的机制性理解,以及它是如何转变的。
所有癌症类型的慢性神经炎症,以开发更有效的治疗干预措施。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel L. Marks其他文献
Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients
肥胖减肥手术患者的血清瘦素水平、肝脏瘦素受体转录和非酒精性脂肪性肝炎的临床预测因子
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
D. Le;Daniel L. Marks;E. Lyle;Christopher L. Corless;B. Diggs;B. A. Jobe;Tom S. Kay;Clifford W. Deveney;Bruce M. Wolfe;C. Roberts;Robert W. O’Rourke - 通讯作者:
Robert W. O’Rourke
Rapid prototyping lightweight millimeter wave antenna and waveguide with copper plating
快速原型制作轻型毫米波天线和镀铜波导
- DOI:
10.1109/irmmw-thz.2015.7327539 - 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Ruoyu Zhu;Daniel L. Marks - 通讯作者:
Daniel L. Marks
Daniel L. Marks的其他文献
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{{ truncateString('Daniel L. Marks', 18)}}的其他基金
PQ6: Therapeutic approaches for autonomic and neuroendocrine dysfunction in cancer cachexia
PQ6:癌症恶病质自主神经和神经内分泌功能障碍的治疗方法
- 批准号:
10303658 - 财政年份:2021
- 资助金额:
$ 39.37万 - 项目类别:
PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
PQ6:Lipocalin-2 作为预防癌症恶病质的治疗靶点
- 批准号:
10379260 - 财政年份:2021
- 资助金额:
$ 39.37万 - 项目类别:
PQ6: Therapeutic approaches for autonomic and neuroendocrine dysfunction in cancer cachexia
PQ6:癌症恶病质自主神经和神经内分泌功能障碍的治疗方法
- 批准号:
10490306 - 财政年份:2021
- 资助金额:
$ 39.37万 - 项目类别:
Exosomes as Endocrine Signaling Molecules in Cancer Cachexia
外泌体作为癌症恶病质的内分泌信号分子
- 批准号:
9906180 - 财政年份:2018
- 资助金额:
$ 39.37万 - 项目类别:
Exosomes as Endocrine Signaling Molecules in Cancer Cachexia
外泌体作为癌症恶病质的内分泌信号分子
- 批准号:
10171402 - 财政年份:2018
- 资助金额:
$ 39.37万 - 项目类别:
Exosomes as Endocrine Signaling Molecules in Cancer Cachexia
外泌体作为癌症恶病质的内分泌信号分子
- 批准号:
10394305 - 财政年份:2018
- 资助金额:
$ 39.37万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
8994016 - 财政年份:2014
- 资助金额:
$ 39.37万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
8845181 - 财政年份:2014
- 资助金额:
$ 39.37万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
9079439 - 财政年份:2014
- 资助金额:
$ 39.37万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
8680933 - 财政年份:2014
- 资助金额:
$ 39.37万 - 项目类别:
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