Cathepsin B in the development of Focal Segmental Glomerulosclerosis (B14#)

组织蛋白酶 B 在局灶性节段性肾小球硬化症 (B14

• 批准号: 418914886
• 金额: --
• 依托单位: Anatomisches Institut
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418914886?language=en
• 关键词: Cathepsin; development; Focal; Segmental; Glomerulosclerosis

Our aim of this study is to identify the role of cathepsin B in glomerular disease progression during the development of a focal segmental glomerulosclerosis causing the nephrotic syndrome. Additionally, the impact of paracrine cathepsin B in the renal collecting duct on edema formation and hypertension, important features of the nephrotic syndrome, will be analyzed. We plan to investigate the transmission of a glomerular disease towards the collecting duct system by extracellular vesicles and translate our knowledge to bedside and identify whether cathepsin B and other urinary proteases are markers for the frequent relapse of a nephrotic syndrome.

本研究的目的是确定组织蛋白酶B在局灶节段性肾小球硬化导致肾病综合征的发展过程中肾小球疾病进展中的作用。此外，将分析肾集合管中旁分泌组织蛋白酶B对水肿形成和高血压（肾病综合征的重要特征）的影响。我们计划研究肾小球疾病通过细胞外囊泡向集合管系统的传播，并将我们的知识转化到床边，并确定组织蛋白酶B和其他尿蛋白酶是否是肾病综合征频繁复发的标志物。