Cathepsin B in the development of Focal Segmental Glomerulosclerosis (B14#)

我们这项研究的目的是确定组织蛋白酶B在局灶节段性肾小球硬化导致肾病综合征期间肾小球疾病进展中的作用。此外，还将分析肾集管旁分泌组织蛋白酶B对肾病综合征重要特征水肿形成和高血压的影响。我们计划调查肾小球疾病通过细胞外囊泡向收集管系统的传播，并将我们的知识转化为床边，并确定组织蛋白酶B和其他尿蛋白酶是否是肾病综合征频繁复发的标志。

Our aim of this study is to identify the role of cathepsin B in glomerular disease progression during the development of a focal segmental glomerulosclerosis causing the nephrotic syndrome. Additionally, the impact of paracrine cathepsin B in the renal collecting duct on edema formation and hypertension, important features of the nephrotic syndrome, will be analyzed. We plan to investigate the transmission of a glomerular disease towards the collecting duct system by extracellular vesicles and translate our knowledge to bedside and identify whether cathepsin B and other urinary proteases are markers for the frequent relapse of a nephrotic syndrome.