BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10481027
• 负责人: Nihal Ahmad
• 金额: --
• 依托单位: WM S. MIDDLETON MEMORIAL VETERANS HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2029-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10481027
• 关键词: Academia; Affect; Afghanistan; Antioxidants; Area; Award; Berry; Biochemical; Biology; Book Chapters; Cancer Biology; Cancer Patient; Carcinoma; Chemopreventive Agent; Clinical; Collaborations; Country; Data; Deacetylase; Department of Defense; Dermatology; Development; Dioxins; Environment; Event; Exposure to; Extramural Activities; Faculty; Family; Funding; Funding Agency; Goals; Grapes; Hand; Healthcare; Herbicides; Human; Incidence; Industry; International; Investigational Therapies; Iraq; Journals; Laboratories; Lead; Life; Malignant Neoplasms; Malignant neoplasm of prostate; Melatonin; Mentors; Micronutrients; Middle East; Military Personnel; Mission; Mitotic; Molecular; Names; Neoplasms; Nicotinamide adenine dinucleotide; Nuts; Oncogenes; Oncology; PLK1 gene; Paper; Peer Review Grants; Pharmacology; Photobiology; Photochemistry; Pineal gland; Positioning Attribute; Postdoctoral Fellow; Prevention; Protein Family; Protein-Serine-Threonine Kinases; Publishing; Radiation; Reporting; Research; Research Personnel; Research Support; Resveratrol; Risk; Role; Scientist; Selenium; Services; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Sirtuins; Skin Cancer; Source; Study Section; Therapeutic; Toxicology; UV Radiation Exposure; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Veterans Health Administration; Vietnam; Vitamin E; Wisconsin; Work; World War II; anticancer research; base; cancer diagnosis; career; druggable target; editorial; experience; frontier; improved; indexing; interest; melanoma; member; military veteran; neoplasm registry; novel; novel strategies; operation; phytoalexins; red wine; tumor progression; ultraviolet irradiation; undergraduate student

This proposed Research Career Scientist award is to support the activities of Dr. Nihal Ahmad, an established Department of Veterans Affairs (VA) investigator, allowing him to expand his scientific, mentoring and service contributions. Dr. Ahmad’s long-term goal is to improve the quality of human life, including that of Veterans, through my research. Dr. Ahmad’s laboratory focuses on two broad and complementary research areas: 1) cancer biology and 2) prevention and experimental therapeutics of cancer. The major goal of his ongoing research is to define the critical molecular and biochemical events that occur during cancer development and progression to help identify novel targets and strategies for cancer management. While Dr. Ahmad’s laboratory is involved in understanding epithelial cancer in general, his major recent focus has been on skin- and prostate- cancers, both of which disproportionally affect the Veteran population. Dr. Ahmad’s current VA sponsored research focuses on identifying the mechanism of melanoma development and progression. Importantly, melanoma is among the five most frequently diagnosed cancers among VA cancer patients. In addition, the US military engages in missions all over the world, including recently in the Middle East (Iraq and Afghanistan). Deployment to these regions is associated with significant UV radiation exposure that increases the risk for malignant melanoma in the Veterans returning from these areas. Thus, Dr. Ahmad’s research findings may lead to identification of novel strategies for the management of this deadly neoplasm; and is relevant and significant to the health care of Veterans and directly in line with the mission of the Department of Veterans Affairs. The results of Dr. Ahmad’s research are published in a wide range of high-impact scientific journals. He has published more than 208 papers, 176 published abstracts and several book chapters (I have published more than 208 papers, 176 published abstracts and several book chapters (Total Citations: 28,413; h-index, 83; i10-index: 172; Source: Google Scholar; 08/2021). Dr. Ahmad is internationally recognized researcher. He serves as an Associate Editor of multiple well- respected journals, namely Toxicology and Applied Pharmacology, Journal of Oncology, Journal of Skin Cancer, and Frontiers in Oncology and Photochemistry and Photobiology, and he is a member of the Editorial Board for several other journals. He is regularly invited to participate in the peer-review of grants for national and international funding agencies, including the National Institutes of Health and the Department of Defense. He has recently completed his term as a Charter Member of the Radiation Therapeutics and Biology (RTB) Study Section of the NIH. In addition, he has mentored numerous junior scientists at all levels (undergraduate, graduate, post-doctoral, and junior faculty). Most of his previous trainees/mentees have been successful in obtaining independent positions in academia and industry. In addition, Dr. Ahmad has developed extensive collaborations with numerous scientists within the VA and at the University of Wisconsin, other universities in the US, and outside the country (internationally). Most of his collaborations have been very successful resulting in numerous papers and extramural funding.

这项拟议的研究职业科学家奖是为了支持博士的活动。 成立退伍军人事务部（VA）调查员，使他能够扩大他的科学，指导 服务贡献。艾哈迈德博士的长期目标是提高人类生活质量，包括 退伍军人，通过我的研究。艾哈迈德博士的实验室专注于两个广泛和互补的研究 领域：1）癌症生物学和2）癌症的预防和实验治疗。他的主要目标是 目前正在进行的研究是确定癌症发生过程中的关键分子和生物化学事件， 发展和进步，以帮助确定新的目标和癌症管理的战略。虽然博士。 Ahmad的实验室参与了对上皮癌的总体了解，他最近的主要关注点是 皮肤癌和前列腺癌，这两种癌症都会对退伍军人产生不良影响。 艾哈迈德博士目前的VA赞助的研究重点是确定黑色素瘤的机制 发展和进步。重要的是，黑色素瘤是五种最常见的癌症之一， 在退伍军人管理局癌症患者中此外，美军在世界各地从事任务，包括 最近在中东（伊拉克和阿富汗）。部署到这些地区， 紫外线辐射暴露，增加了从这些退伍军人返回恶性黑色素瘤的风险 地区因此，艾哈迈德博士的研究结果可能会导致识别新的战略管理 这种致命的肿瘤;是相关的和重要的退伍军人的医疗保健，并直接符合 退伍军人事务部的使命。艾哈迈德博士的研究结果发表在广泛的 高影响力的科学期刊。发表论文208篇，摘要176篇， 几本书的章节（我已发表超过208篇论文、176篇出版摘要和几本书 章节（总引文：28，413; h-index，83; i10-index：172;来源：Google Scholar; 08/2021）。 艾哈迈德博士是国际公认的研究员。他是一位优秀的编辑， 受人尊敬的期刊，即《毒理学与应用药理学》、《肿瘤学杂志》、《皮肤杂志》 癌症，肿瘤学和光化学和光生物学前沿，他是编辑部成员 其他几家期刊的董事会。他经常应邀参加国家赠款的同行审查。 以及国际资助机构，包括美国国立卫生研究院和国防部。 他最近完成了他作为放射治疗和生物学（RTB）特许会员的任期。 美国国立卫生研究院研究科。此外，他还指导了许多各级（本科， 研究生、博士后和初级教师）。他以前的大多数学员/学员都成功地在 在学术界和工业界获得独立地位。此外，艾哈迈德博士还开发了广泛的 与弗吉尼亚州和威斯康星州大学的众多科学家合作， 美国和国外（国际）。他的大部分合作都非常成功 导致了大量的论文和校外资金。