Homogeneously catalyzed cleavage of C-O bonds and related reactions

该项目的目的是进一步开发C-O键的均相钯催化氢解。它包括机械催化剂结构-活性关系研究和动力学研究，以确定更活性和选择性的催化剂，并深入了解反应机理。计划进行系统的底物范围筛选，包括各种官能团和结构特征的评价。该转化的合成效用将在生物活性化合物的合成以及天然化合物的后期功能化中得到证明。应采用相应的手性催化剂开发立体选择性变化。这包括叔醇的动力学拆分、去对称化和对映选择性氢解。此外，相关的还原性半频哪醇重排应进行调查。

The aim of the project is further development of homogeneous palladium-catalysed hydrogen-lysis of C-O bonds. It includes a mechanistic catalyst structure-activity relationship study and kinetic investigation in order to identify a more active and selective catalyst and to gain insight into the reaction mechanism. A systematic substrate scope screening is planned, including evaluation of various functional groups and structural features. The synthetic utility of the transformation will be demonstrated in synthesis of biologically active compounds, as well as in the late stage functionalization of natural compounds. A stereoselective variation should be developed employing a corresponding chiral catalyst. This will include kinetic resolution, desymmetrization and enantioselective hydrogenolysis of tertiary alcohols. Furthermore, the related reductive semipinacol rearrangement should be investigated.