Homogeneously catalyzed cleavage of C-O bonds and related reactions

均相催化C-O键断裂及相关反应

• 批准号: 423260492
• 负责人: Professorin Dr. Ivana Fleischer
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/423260492?language=en
• 关键词: Homogeneously; catalyzed; cleavage; bonds; related

The aim of the project is further development of homogeneous palladium-catalysed hydrogen-lysis of C-O bonds. It includes a mechanistic catalyst structure-activity relationship study and kinetic investigation in order to identify a more active and selective catalyst and to gain insight into the reaction mechanism. A systematic substrate scope screening is planned, including evaluation of various functional groups and structural features. The synthetic utility of the transformation will be demonstrated in synthesis of biologically active compounds, as well as in the late stage functionalization of natural compounds. A stereoselective variation should be developed employing a corresponding chiral catalyst. This will include kinetic resolution, desymmetrization and enantioselective hydrogenolysis of tertiary alcohols. Furthermore, the related reductive semipinacol rearrangement should be investigated.

该项目的目的是进一步发展均相钯催化氢裂解C-O键。包括机理催化剂的构效关系研究和动力学研究，以确定更具活性和选择性的催化剂，进一步了解反应机理。一个系统的底物范围筛选计划，包括各种官能团和结构特征的评估。转化的合成效用将在生物活性化合物的合成以及天然化合物的后期功能化中得到证明。应采用相应的手性催化剂开发立体选择性变体。这将包括动力学分解，去对称和叔醇的对映选择性氢解。此外，相关的还原半品萘酚重排还有待进一步研究。