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Characterization of the EchA20 catalyzed ring cleavage during Cholesterol Catabolism in Mycobacterium tuberculosis

Characterization of the EchA20 catalyzed ring cleavage during Cholesterol Catabolism in Mycobacterium tuberculosis
结核分枝杆菌胆固醇分解代谢过程中 EchA20 催化环裂解的表征
批准号：
406445
负责人：
Chorolovski Jessica M
金额：
$1.27万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-12-01 至 2019-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=406445&lang=en
关键词：
Cholesterol Crystallography Directed Mutagenesis Echa20 Enzyme Kinetics Metabolic Pathways Metabolite Mycobacterium Tuberculosis Novel Theraputics Pathogenicity

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Mycobacterium tuberculosis (Mtb), the bacterium responsible for the fatal lung disease tuberculosis, infects one third of the world’s population and causes over 1.5 million deaths annually. The increasing prevalence of drug-resistant strains intensifies t
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