Nickel-catalyzed C-S coupling of challenging substrates

具有挑战性的基材的镍催化 C-S 偶联

• 批准号: 517656950
• 负责人: Professorin Dr. Ivana Fleischer
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/517656950?language=en
• 关键词: Nickel; catalyzed; coupling; challenging; substrates

Aryl thioethers are important compounds that are directly used in many areas, such as agrochemical or pharmaceutical industry, or they serve as important synthetic intermediates. The metal-catalyzed coupling of aryl chlorides and triflates with thiols constitutes a direct method for their synthesis. Although there are already many examples of this reaction, they often have many disadvantages (e.g. high temperatures and catalyst loadings). In addition, many substrates are difficult to convert because of their reactivity (aryl chlorides) or for steric reasons. With this project, we want to close this gap and use nickel as a base metal catalyst. Our preliminary work provides a good basis for our effort. The aim is to identify catalysts and conditions that would allow the coupling of demanding substrates. At the same time, the development of novel enantioselective C-S couplings is planned. Mechanistic studies are an important part of the project. In addition to explaining the individual steps of the catalytic cycle, they should provide essential information for further improvement of the catalysts.

芳基硫醚是重要的化合物，可直接用于农业化学或制药工业等许多领域，或作为重要的合成中间体。芳基氯和三氟甲磺酸酯与硫醇的金属催化偶联构成了其合成的直接方法。尽管该反应已经有很多例子，但它们通常有许多缺点（例如高温和催化剂负载）。此外，许多底物由于其反应性（芳基氯）或空间原因而难以转化。通过这个项目，我们希望缩小这一差距并使用镍作为贱金属催化剂。我们的前期工作为我们的努力奠定了良好的基础。目的是确定能够耦合要求较高的底物的催化剂和条件。同时，计划开发新型对映选择性 C-S 偶联。机理研究是该项目的重要组成部分。除了解释催化循环的各个步骤之外，它们还应该为进一步改进催化剂提供必要的信息。