From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution

从发育稳定性到机体衰老：Hox 基因和端粒对生命史进化的影响

• 批准号: LX0774859
• 负责人: Prof Mats Olsson
• 金额: $ 2.61万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0774859
• 关键词: developmental; stability; organismic; senility; Hox

Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect their underlying genetic mechanism. Furthermore, we can also assess how these animals survive and reproduce in relation to how quickly they age, which can be measured by assessing the shortening of telomeres per unit time. Thus, this collaboration provides an opportunity to train Australian researchers and in that process generate very high profile research.

澳大利亚受益于在新的突破性生物技术方面培训研究人员和技术人员，并将这种知识应用于高度宣传的研究领域的相关尖端问题。该项目包含这两个要素。我们的模型物种（蜥蜴）的后代畸形水平相对较高（约15%），这使得更有可能检测到其潜在的遗传机制。此外，我们还可以评估这些动物的生存和繁殖与它们衰老速度的关系，这可以通过评估单位时间内端粒的缩短来衡量。因此，这种合作为培训澳大利亚研究人员提供了一个机会，并在此过程中产生了非常引人注目的研究。