Activation of beating of cardiac clusters through mechanical loading and study of synchronization mechanisms

通过机械负载激活心脏簇的跳动和同步机制的研究

• 批准号: 423918021
• 负责人: Professor Dr. Valentin L. Popov
• 金额: --
• 依托单位: Faculty of Engineering
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/423918021?language=en
• 关键词: Activation; beating; cardiac; clusters; through

This is the second phase of a cooperative project studying the response of clusters of cardiac cells to mechanical loading. The focus of the second phase of the project will be understanding and modeling of synchronization mechanisms of cells of a single cluster under mechanical loading; of two clusters (cardiac spheroids) with mechanical communication; as well as three and more clusters. Further, the possible synergy of electrical and mechanical communication will be elucidated and implemented in a corresponding multi-field model of the active medium. The role of damage of inter-cell communication and of regeneration will be studied experimentally and theoretically, the latter being an important goal for medical applications.Experimental study will be carried out at the Yokohama National University and theoretical modeling at TU Berlin. Modeling will be done using the Method of Dimensionality Reduction. Comparison of both studies will be used for validation of the model and for parameter identification. Using a modification of the experimental set-up, the interrelation of mechanical loading of clusters and possible electrical fields will be studied and implemented first into a continuum model of the medium and then into a contact model. A further important work package will be devoted to irreversible changes in properties of the medium – both damages and regeneration which will be studied experimentally, theoretically and numerically using the Boundary Element Method (TU Berlin) and Finite Element Method (Yokohama National University).

这是一个合作项目的第二阶段，该项目研究心肌细胞簇对机械负荷的反应。该项目第二阶段的重点将是了解和模拟机械负荷下单个集群的细胞同步机制；两个集群(心脏球体)的细胞在机械连接下的同步机制；以及三个或更多集群的同步机制。此外，电和机械通信的可能的协同作用将被阐明，并在相应的有源介质的多场模型中实现。细胞间通讯的损伤和再生的作用将从实验和理论上进行研究，后者是医学应用的一个重要目标。实验研究将在横滨国立大学进行，理论模型将在柏林理工大学进行。将使用降维的方法进行建模。两项研究的比较将用于模型的验证和参数识别。通过对实验装置的改进，团簇的机械载荷和可能的电场之间的相互关系将被研究，并首先被实现为介质的连续模型，然后被实现为接触模型。另一个重要的工作包将致力于介质性质的不可逆变化--包括损伤和再生，将使用边界元方法(柏林理工大学)和有限元方法(横滨国立大学)对其进行实验、理论和数值研究。