Adaptation mechanisms of actinomycetes to the production of a variety of antibiotics (B05)

放线菌对多种抗生素生产的适应机制（B05）

• 批准号: 425876804
• 金额: --
• 依托单位: Lehrstuhl für Mikrobielle Wirkstoffe
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/425876804?language=en
• 关键词: Adaptation; mechanisms; actinomycetes; production; variety

We will study synergistic effects and the coevolution of antibiotics produced by the same organisms. Since the most gifted natural product producers encode biosynthetic gene clusters for multiple antibiotic compounds within their genome, we plan to analyze how the cell adapts to the production of multiple antibiotics, especially considering synergistic effects of antibiotics with similar targets. Using the glycopeptide antibiotics and their producers as a model system, we will look at the possible coevolution of these with other antibiotics, study genomic adaptations and analyze specific pathways both in silico and in vivo.

我们将研究由同一生物产生的抗生素的协同效应和共同进化。由于最有天赋的天然产物生产者在其基因组中编码多种抗生素化合物的生物合成基因簇，我们计划分析细胞如何适应多种抗生素的生产，特别是考虑具有相似靶点的抗生素的协同效应。使用糖肽抗生素及其生产者作为模型系统，我们将研究这些抗生素与其他抗生素可能的共同进化，研究基因组适应并分析在硅和体内的特定途径。