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Preclinical Ultra High Frequency Ultrasound imaging system

临床前超高频超声成像系统

基本信息

批准号：
426125151
负责人：
金额：
--
依托单位：
Ruhr-Universität Bochum
依托单位国家：
德国
项目类别：
Major Research Instrumentation
财政年份：
2019
资助国家：
德国
起止时间：
2018-12-31 至无数据
项目状态：
未结题

来源：
https://gepris.dfg.de/gepris/projekt/426125151?language=en
关键词：
Preclinical Ultra Frequency Ultrasound imaging

项目摘要

Investigation of novel therapeutic strategies for the treatment of heart failure focussing on inflammation, metabolism and genetics in mouse modelsA variety of pathological factors like inflammation, oxidative stress, metabolic disorders as well as genetic mutations cause impairment of cardiac function. Heart failure is one the leading causes for mortality and morbidity in an ageing population. Thus, the assessment of cardiac function is of great importance in clinical practice as well as in experimental research. The main techniques to determine cardiac function are magnetic resonance tomography (MRT) and echocardiography. MRT is not only producing high expenses but is also time- and personnel-consuming. In consequence, echocardiography is the standard technique for the assessment of cardiac function in clinical practice and basic and translational research. In the course of the assignment of Prof. Dr. Volker Rudolph to the position of the director of the clinic for general and interventional cardiology and angiology at HDZ NRW in summer 2018 he is currently, together with Dr. Anna Klinke, establishing a new basic research group at HDZ NRW. The successful investigation of cardiovascular pathomechanisms in mouse models, which has been conducted so far, will be continued and enlarged and collaborations with research groups at HDZ NRW will be established and intensified in order to design an application for a collaborative research group. Using an ultrasound imaging device for rodents is essential for the planned projects and is a central component of future research at HDZ NRW.

心力衰竭治疗新策略的研究重点是小鼠模型中的炎症、代谢和遗传学多种病理因素如炎症、氧化应激、代谢紊乱以及基因突变导致心功能受损。心力衰竭是老龄化人群中死亡和发病的主要原因之一。因此，心脏功能的评价在临床实践和实验研究中具有重要意义。确定心脏功能的主要技术是磁共振断层扫描（MRT）和超声心动图。捷运不仅费用高，而且耗时耗人。因此，超声心动图是临床实践以及基础和转化研究中评估心脏功能的标准技术。Volker Rudolph教授博士于2018年夏天被任命为HDZ NRW普通和介入心脏病和血管病诊所主任，目前他正与安娜Klinke博士一起在HDZ NRW建立一个新的基础研究小组。到目前为止，已经进行的小鼠模型心血管病理机制的成功研究将继续和扩大，并将建立和加强与HDZ NRW研究小组的合作，以便为合作研究小组设计应用程序。对啮齿动物使用超声成像设备对于计划中的项目至关重要，也是HDZ NRW未来研究的核心组成部分。