Preclinical Ultra High Frequency Ultrasound imaging system

从小鼠模型的炎症、代谢和遗传学角度探讨心力衰竭治疗的新策略炎症、氧化应激、代谢紊乱以及基因突变等多种病理因素导致心功能损害。心脏衰竭是人口老龄化导致死亡和发病的主要原因之一。因此，心功能的评估在临床和实验研究中都具有重要的意义。确定心功能的主要技术是磁共振断层扫描（MRT）和超声心动图。捷运不仅费用高，而且耗费时间和人力。因此，超声心动图是临床实践、基础研究和转化研究中评估心功能的标准技术。2018年夏季，Volker Rudolph教授被任命为HDZ NRW普通和介入性心脏病学和血管学诊所主任，目前他正在与Anna Klinke博士一起在HDZ NRW建立一个新的基础研究小组。到目前为止，在小鼠模型中成功进行的心血管病理机制的研究将继续和扩大，并将与HDZ NRW的研究小组建立和加强合作，以便为合作研究小组设计一个应用程序。对啮齿类动物使用超声成像设备对于计划中的项目至关重要，也是HDZ NRW未来研究的核心组成部分。

Investigation of novel therapeutic strategies for the treatment of heart failure focussing on inflammation, metabolism and genetics in mouse modelsA variety of pathological factors like inflammation, oxidative stress, metabolic disorders as well as genetic mutations cause impairment of cardiac function. Heart failure is one the leading causes for mortality and morbidity in an ageing population. Thus, the assessment of cardiac function is of great importance in clinical practice as well as in experimental research. The main techniques to determine cardiac function are magnetic resonance tomography (MRT) and echocardiography. MRT is not only producing high expenses but is also time- and personnel-consuming. In consequence, echocardiography is the standard technique for the assessment of cardiac function in clinical practice and basic and translational research. In the course of the assignment of Prof. Dr. Volker Rudolph to the position of the director of the clinic for general and interventional cardiology and angiology at HDZ NRW in summer 2018 he is currently, together with Dr. Anna Klinke, establishing a new basic research group at HDZ NRW. The successful investigation of cardiovascular pathomechanisms in mouse models, which has been conducted so far, will be continued and enlarged and collaborations with research groups at HDZ NRW will be established and intensified in order to design an application for a collaborative research group. Using an ultrasound imaging device for rodents is essential for the planned projects and is a central component of future research at HDZ NRW.