Rhodium nanocatalysts and hyperpolarization - synthesis and production of biomedical contrast agents

铑纳米催化剂与超极化——生物医学造影剂的合成与生产

• 批准号: 426677227
• 负责人: Dr. Stefan Glöggler
• 金额: --
• 依托单位: Forschungsgruppe NMR-Signalverstärkung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426677227?language=en
• 关键词: Rhodium; nanocatalysts; hyperpolarization; synthesis; production

Rhodium is a metal with a variety of catalytic applications due to its unique properties. One example of a reaction is the hydrogenation. In this proposal I am aiming to achieve the goal of synthesizing potent heterogeneous catalysts which are going to be utilized for the hyperpolarization of metabolites. Hyperpolarization is a nuclear magnetic resonance (NMR) technique which enhances signals over four orders of magnitude. A main field of application is the medical diagnostics. For diagnostics, hyperpolarized metabolites are injected into an organism and their metabolic conversion is imaged in realtime. One hyperpolarization method is based on the hydrogenation with para-hydrogen. In para-hydrogen, a nuclear singlet state can be populated up to 100% (100% spin order). This spin order can subsequently be converted into observable magnetization by means of a hydrogenation reaction. For metabolites, more than 10 000fold signal enhancements can be achieved. Mainly homogeneous catalysts are being utilized for the para-hydrogenation process. Homogeneous catalysts can hardly be separated on the timescale of a hyperpolarization experiment and raise toxicity concerns. The synthesis of a heterogeneous catalyst as pursued in this proposal will lead to possibilities to create clean metabolites for medical diagnostics. This is achieved by designing particles that generate high levels of hyperpolarization and can be filtered off from a molecule of interest.

铑是一种具有多种催化应用的金属，由于其独特的性质。反应的一个实例是氢化。在这个提议中，我的目标是实现合成有效的非均相催化剂的目标，这些催化剂将用于代谢物的超极化。超极化是一种核磁共振（NMR）技术，其增强信号超过四个数量级。主要应用领域是医疗诊断。对于诊断，将超极化代谢物注射到生物体中，并实时成像其代谢转化。一种超极化方法是基于仲氢氢化。在仲氢中，核单重态可以达到100%（100%自旋序）。该自旋序随后可以通过氢化反应转化为可观察到的磁化。对于代谢物，可以实现超过10000倍的信号增强。对位氢化工艺主要使用均相催化剂。均相催化剂在超极化实验的时间尺度上几乎不能分离，并且引起毒性问题。如在该提议中所追求的多相催化剂的合成将导致产生用于医学诊断的清洁代谢物的可能性。这是通过设计产生高水平超极化的粒子来实现的，并且可以从感兴趣的分子中过滤掉。