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Molecular Machines made from Lasso Peptides

由套索肽制成的分子机器

基本信息

批准号：
427725459
负责人：
Dr. Hendrik V. Schröder
金额：
--
依托单位：
Institut für Organische Chemie I
依托单位国家：
德国
项目类别：
Research Fellowships
财政年份：
2019
资助国家：
德国
起止时间：
2018-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/427725459?language=en
关键词：
Molecular Machines made Lasso Peptides

项目摘要

A fundamental idea of nanotechnology is the miniaturization of functional systems, e.g. the construction of molecular machines and their operation at the nanoscale. Mechanically interlocked molecules such as rotaxanes or catenanes are promising prototypes for synthetic molecular machines. With the awarding the Nobel Prize in Chemistry to this field in 2016, this research has been pushed into the view of the general public. However, the lack of biocompatibility and challenging multi-step synthesis complicate applications of these synthetic nanodevices. Promising alternatives to synthetic systems are natural products with mechanically interlocked structures such as lasso peptides. Their intertwined structure can be easily manipulated by tools of chemistry and biochemistry, which allows a conversion into rotaxanes and catenanes. Additionally, some lasso peptides can undergo reversible conformational changes, which make them suitable as molecular switches. In this project, novel peptide-based architectures will be constructed suitable for the use as molecular machines. In a first step, lasso peptides will be chemically modified to enable intermolecular linkage. Molecular self-assembly utilizing these modified peptide building blocks will subsequently lead to more complex catenanes. Through a rational design controlled molecular motion can be generated in the resulting mechanically interlocked molecules. Thus, lasso peptide-based systems offer a largely unexplored, yet promising alternative to synthetic molecular machines.

纳米技术的基本思想是功能系统的小型化，例如分子机器的构造及其在纳米尺度上的操作。机械联锁分子（例如轮烷或索烷）是合成分子机器的有前途的原型。随着2016年该领域获得诺贝尔化学奖，这项研究被推入了大众的视野。然而，缺乏生物相容性和具有挑战性的多步骤合成使这些合成纳米器件的应用变得复杂。合成系统的有前途的替代品是具有机械互锁结构的天然产物，例如套索肽。它们相互缠绕的结构可以很容易地通过化学和生物化学工具来操纵，从而可以转化为轮烷和索烷。此外，一些套索肽可以经历可逆的构象变化，这使得它们适合作为分子开关。在该项目中，将构建适合用作分子机器的新型基于肽的架构。第一步，将对套索肽进行化学修饰以实现分子间连接。利用这些修饰的肽结构单元进行分子自组装将随后产生更复杂的索烷。通过合理的设计，可以在所得的机械联锁分子中产生受控的分子运动。因此，基于套索肽的系统为合成分子机器提供了一种很大程度上未经探索但有前途的替代方案。