RNA regulatory mechanisms in cardiac metabolism (B07)

我们已经在小鼠模型中证明了在心脏肥厚和心力衰竭中对增强子模板rna （eRNAs）的需求。拟议的项目建立在这一观察的基础上，旨在评估人类疾病模型（ips衍生的心脏类器官）中特定功能验证的erna的病理生理相关性，并测试这些分子在小鼠心脏病模型中的治疗性操作。该项目的总体目标是确定临床相关的eRNA靶点，用于治疗人类心脏病。

We have demonstrated in mouse models a requirement for enhancer-templated RNAs (eRNAs) in cardiac cardiac hypertrophy and heart failure. The proposed project builds on this observation and aims to assess the pathophysiologic relevance of specific functionally validated eRNAs in human disease models (iPS-derived cardiac organoids) and test the therapeutic manipulation of these molecules in mouse models of heart disease. The overarching goal of this project is to identify clinically-relevant eRNA targets for the treatment of human heart disease.