Mechanisms of microglia-induced circuit remodeling in post-stroke recovery

这个项目的目的是研究小胶质细胞促进急性中风后恢复的机制。我们将采用新的工具来调节小胶质细胞的功能，并研究它们对功能恢复和远距离神经元连接的影响。具体来说，我们将关注小胶质细胞在轴突重组过程中调节轴突完整性和髓鞘形成的作用，以及慢性小胶质细胞激活的apoe途径。为此，我们将结合体内成像、基因修饰和超微结构分析的互补工具。

The aim of this project is to investigate the mechanisms by which microglia promote recovery after acute stroke. We will adopt novel tools to modulate microglial function and study their impact on functional recovery and long-range neuronal connectivity. Specifically, we will focus on the role of microglia in modulating axon integrity and myelination during axonal reorganization and the ApoE-pathway of chronic microglial activation. For this we will combine complementary tools of in vivo imaging, genetic modification and ultrastructural analysis.