Mechanisms of microglia-induced circuit remodeling in post-stroke recovery

中风后恢复中小胶质细胞诱导的回路重塑机制

• 批准号: 428663564
• 负责人: Professor Dr. Arthur Liesz
• 金额: --
• 依托单位: Institut für Schlaganfall- und Demenzforschung (ISD)
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/428663564?language=en
• 关键词: Mechanisms; microglia; induced; circuit; remodeling

The aim of this project is to investigate the mechanisms by which microglia promote recovery after acute stroke. We will adopt novel tools to modulate microglial function and study their impact on functional recovery and long-range neuronal connectivity. Specifically, we will focus on the role of microglia in modulating axon integrity and myelination during axonal reorganization and the ApoE-pathway of chronic microglial activation. For this we will combine complementary tools of in vivo imaging, genetic modification and ultrastructural analysis.

本项目的目的是研究小胶质细胞促进急性卒中后恢复的机制。我们将采用新的工具来调节小胶质细胞的功能，并研究它们对功能恢复和远程神经元连接的影响。具体来说，我们将集中在小胶质细胞在调节轴突的完整性和髓鞘形成过程中轴突重组和慢性小胶质细胞活化的ApoE途径的作用。为此，我们将结合联合收割机体内成像，遗传修饰和超微结构分析的互补工具。