Coordination Funds

协调基金

• 批准号: 508316221
• 负责人: Professor Dr. Arthur Liesz
• 金额: --
• 依托单位: Institut für Schlaganfall- und Demenzforschung (ISD)
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/508316221?language=en
• 关键词: Coordination; Funds

Ischemic stroke is the primary cause of long-term disability and the third leading cause of death in industrialized countries. Current treatments for stroke are limited, and preclinical experimental findings often fail in clinical trials. Therefore, new avenues of basic research with high translation potential are desperately needed in order to develop effective therapeutic strategies. Although the development of local inflammatory processes in the ischemic brain is a known phenomenon, precisely how these immune processes are linked to the secondary expansion of the infarct area and the role of the immune system in post-stroke regeneration remain poorly understood. Interestingly, while cerebral ischemia is traditionally not considered a classic neuroinflammatory disorder, stroke induces a plethora of immune responses similar to the responses that occur in autoimmune brain diseases. Moreover, the stroke-related acute brain injury has a robust effect on the peripheral immune system, inducing a multiphasic immune response. The reciprocal interaction between immunological responses and brain injury is poorly understood, particularly with respect to the mechanisms underlying recovery following stroke. This research unit ImmunoStroke is focusing on studying the role of immunity in repair mechanisms and long-term recovery following stroke. The projects described for the renewal of this consortium in its second funding period are designed to i) address how immunity modulates the recovery process following stroke; ii) clarify the role of neuroinflammation in stroke patients; and iii) and identify novel markers of post-stroke neuroinflammation. These goals will be achieved using cutting-edge technologies and new treatment paradigms in order to understand and modulate the immune responses that occur following experimental stroke. Importantly, the preclinical experiments will be highly standardized, the key findings will be validated in multicenter preclinical RCTs, and the experiments will be supported by analyses performed using stroke patients.

缺血性中风是工业化国家长期残疾的主要原因和第三大死亡原因。目前中风的治疗方法是有限的，临床前实验结果往往在临床试验中失败。因此，迫切需要具有高翻译潜力的基础研究的新途径，以开发有效的治疗策略。虽然局部炎症过程在缺血性脑中的发展是一种已知的现象，但这些免疫过程如何与梗死区域的继发性扩张以及免疫系统在卒中后再生中的作用联系在一起仍然知之甚少。有趣的是，虽然脑缺血传统上不被认为是一种典型的神经炎症性疾病，但中风诱导了大量的免疫反应，类似于自身免疫性脑疾病中发生的反应。此外，中风相关的急性脑损伤对外周免疫系统具有强大的影响，诱导多相免疫应答。免疫反应和脑损伤之间的相互作用知之甚少，特别是关于中风后恢复的机制。该研究单位ImmunoStroke专注于研究免疫在中风后修复机制和长期恢复中的作用。该联盟在其第二个资助期内更新的项目旨在i）解决免疫如何调节中风后的恢复过程; ii）澄清中风患者神经炎症的作用; iii）并确定中风后神经炎症的新标志物。这些目标将使用尖端技术和新的治疗模式来实现，以了解和调节实验性中风后发生的免疫反应。重要的是，临床前实验将高度标准化，关键发现将在多中心临床前RCT中得到验证，并且实验将得到使用中风患者进行的分析的支持。