Synthetic Design and Characterization of Quasi-Lecithin Compounds

准卵磷脂化合物的合成设计和表征

• 批准号: 01470100
• 负责人: YOSHIKAWA Sadao
• 金额: $ 1.02万
• 依托单位: Faculty of Science and Technology, Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01470100/
• 关键词: Amphiphilic Complexes; Molecular Aggregates; Optical Activities; Quasi-Lecithin; Vesicle; ラメラ; 複鎖型両親媒化合物

There is few papers on the preparation of complexes consisting of metal and complex lipids in spite of they have plenty of opportunities to encounter each other in the vital organism.An amphilic cobalt (III) complex containing two long acyl groups was prepared by acylation of the corresponding precursory complex, which has two hydroxyl groups in - and - position, as shown in Fig. 1. A schematic preparation sequence was shown below.In this study, we investigate the preparation methods to obtain the amphiphilic complex more effectively. Following two methods were discussed.1) Through the reaction between metal and complete ligand, in which two hydroxyl groups on - and - position were previously acylated with higher fatty acid.2) Through the acylation of the precursory complex by higher acyl group.In the case 1), the reaction condition at which only hydroxyl group might be acylated regardless of the coexistence of amino and hydroxyl groups, must be developed. The influence of the counter ion of the complex on the solubility were also discussed. Perchlorate anion complex showed most excellent solubility against to the solvent, DMSO.

尽管金属和复合脂质在生命有机体中有大量的机会相互接触，但关于它们的制备的论文却很少。通过对相应前体配合物的酰化，制备了含有两个长酰基的两亲性钴（III）配合物，该前体配合物有两个羟基在-和-位置，如图1所示。准备程序示意图如下所示。在本研究中，我们研究了更有效地获得两亲性配合物的制备方法。讨论了以下两种方法。1)通过金属与完全配体的反应，其中两个羟基上和位置上预先被较高的脂肪酸酰化。2)通过前体配合物被更高的酰基酰化。在情形1)中，必须建立无论氨基和羟基共存，都只能使羟基酰化的反应条件。讨论了配合物的反离子对溶解度的影响。高氯酸盐阴离子配合物对溶剂DMSO的溶解度最好。

项目成果

Morio Yashiro, Katsuya Matsumoto, and Sadao Yoshikawa: "Molecular Aggregates of Mixed Ligand Cobalt (III) Complexes Having One or Two Long Alkyl-Chains" Chem. Letter. 6. 985-989 (1989)

Morio Yashiro、Katsuya Matsumoto 和 Sadao Yoshikawa：“具有一个或两个长烷基链的混合配体钴 (III) 配合物的分子聚集体” Chem。

Shuichi Osanai Sadao Yoshikawa et al.,: "Preparation and Characterization of DoubleーChained Diammonium Cationics and Derived Vesicles" J. Japan Oil Chem. Soc.(Yukagaku).

Shuichi Osanai Sadao Yoshikawa 等人，“双链二铵阳离子和衍生囊泡的制备和表征”J. Japan Oil Chem Soc.（Yukagaku）。

Morio Yashiro Sadao Yoshikawa et al.,: "Mplecular Angreates of Mixed Ligand Cobalt(III)Complexes Having One or Two Long Alky1ーChains" Chem.Letter. (6). 985-989 (1989)

Morio Yashiro Sadao Yoshikawa 等人，“具有一个或两个长烷基 1 链的混合配体钴 (III) 配合物的多角形”Chem.Letter (6)。

Shuichi Osanai, Tomomi Okada, Tomoo Yamamura, and Sadao Yoshikawa.: "Preparation and Characterization of Double-Chained Diammonium Cationics and Derived Vesicles" J. Jpn. 011 Chem. Soc.

Shuichi Osanai、Tomomi Okada、Tomoo Yamamura 和 Sadao Yoshikawa.：“双链二铵阳离子和衍生囊泡的制备和表征”J. Jpn。