Study of regulation of follicle development and oocyte maturation

卵泡发育和卵母细胞成熟调控的研究

基本信息

  • 批准号:
    01480387
  • 负责人:
  • 金额:
    $ 4.42万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 财政年份:
    1989
  • 资助国家:
    日本
  • 起止时间:
    1989 至 1991
  • 项目状态:
    已结题

项目摘要

1. As follicles become maturer, aromatase activity from testosterone to estrogen increased.2. In follicular fluid, there exists a gonadotropin inhibitor, whose activity increases as oocytes become maturer.3. Aromatase inhibitor markedly suppressed DNA syntheses in granulosa cells.4. The amount of glucose of an oocyte in a follicle decreases as the gap junctions between an oocyte and glanulosa cells decreases.5. After fertilization, the glucose content increase gradually up to 4-cell-stage and increases vigorously after 8-cell-stage.6. The glucose content in the embryo exposed to sucrose was lower than that in the control 36 hours after sucrose exposure.7. The crack in gona pellucida exercises no influence on hexokinase and G6PDH activities of embryos 20 hours after the treatment.8. In the rat ovary, the number of follicles rapidly increase up to 21 days old. After 21 days, follicle diameter is mainly responsible for the ovarian enlargement.
1.随着卵泡的成熟,从睾酮到雌激素的芳香化酶活性增加。卵泡液中存在促性腺激素抑制剂,其活性随卵母细胞成熟而增强.芳香酶抑制剂显着抑制颗粒细胞的DNA合成。4.卵泡中卵母细胞的葡萄糖含量随着卵母细胞与腺细胞之间的差距连接的减少而减少.受精后,葡萄糖含量逐渐增加,到4细胞期,到8细胞期后,葡萄糖含量急剧增加。蔗糖处理36 h后,胚胎中葡萄糖含量低于对照.透明性腺破裂对处理后20h胚胎的己糖激酶和G6PDH活性无影响.在大鼠卵巢中,卵泡数量迅速增加,直至21日龄。21天后,卵泡直径是卵巢增大的主要原因。

项目成果

期刊论文数量(35)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Saito H,Sato F,Hirayama T,Yoh M,Hiroi M: "Effects of Clomiphene Citrate on Serum Hormone Levels and Endometrial Thickness in an in Vitro Fertilization and Embryo Transfer Program." Hormone Research. 35 supplel. 39-44 (1991)
Saito H、Sato F、Hirayama T、Yoh M、Hiroi M:“克罗米芬柠檬酸盐对体外受精和胚胎移植计划中血清激素水平和子宫内膜厚度的影响”。
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    0
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Fujimori K,Seki K,Ito K,Kawagoe S,Hiroi M: "BrdU Labelling of Oocytes in Embryonal Stage" I Reproduction.
Fujimori K、Seki K、Ito K、Kawagoe S、Hiroi M:“胚胎期卵母细胞的 BrdU 标记”I 复制。
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    0
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広井 正彦: "顕微受精法(microfertilization)に関する臨床的研究の現況" 臨床婦人科産科. 44(3). 189-194 (1990)
Masahiko Hiroi:“微受精临床研究现状”临床妇产科 44(3) (1990)。
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    0
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Ono, T., Komiya, Y., Kawagoe, S., Hiroi, M.: ""Effect of an Aromatase Inhibitor in Human follicular Fluid on DNA Synthesis of Granulosa cell, Theca Cells and Follicles"" Gynecologic and Obstetric Investigation.
Ono, T.、Komiya, Y.、Kawagoe, S.、Hiroi, M.:“人卵泡液中芳香酶抑制剂对颗粒细胞、卵泡膜细胞和卵泡 DNA 合成的影响”妇产科调查。
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    0
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Saito,N.,Hiroi,M.et al: "Existence and Biochemicsl Analysis of Estradiol Binding Protein(E_2BP)in Normal Menstrual Cycle" Steroids. 52. 383-384 (1988)
Saito,N.,Hiroi,M.等人:“正常月经周期中雌二醇结合蛋白(E_2BP)的存在和生化分析”类固醇。
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    0
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HIROI Masahiko其他文献

HIROI Masahiko的其他文献

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{{ truncateString('HIROI Masahiko', 18)}}的其他基金

Studies on the regulatory mechanism of interaction between the development of ovulatry follicle and ovum in the ovary.
卵巢内排卵卵泡发育与卵子相互作用调控机制的研究。
  • 批准号:
    10671513
  • 财政年份:
    1998
  • 资助金额:
    $ 4.42万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Mechanism of fertilization and embryo development
受精和胚胎发育机制
  • 批准号:
    05404055
  • 财政年份:
    1993
  • 资助金额:
    $ 4.42万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Studies on the control mechanism of menstrual cyclicity from the point of existence type of estrogen in blood
从血液中雌激素存在类型研究月经周期的控制机制
  • 批准号:
    60570767
  • 财政年份:
    1985
  • 资助金额:
    $ 4.42万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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