Effect (s) of maternal antigenic stimulation on the active response of her offspring.

本研究旨在探讨孕期母体免疫对子代免疫反应的影响(S)。孕鼠用T依赖的外源抗原SRBC母体免疫后，其子代的抗SRBC PFC反应受到抑制。我们试图通过将母体细胞分离为T细胞、B细胞和巨噬细胞或T细胞亚群，然后过继地将它们转移到其他正常妊娠小鼠体内，在免疫受孕小鼠的母体淋巴样细胞中鉴定在其后代中诱导这种抑制的细胞种类。结果表明，免疫孕鼠外周血中的CD_4~+T细胞对子代具有免疫抑制作用，孕期母体T细胞可被特异性激活。此外，母体T细胞需要细胞组织才能在其后代中诱导这种免疫抑制。

The present study focused on the influence of maternal immunity during pregnancy on the responsiveness of the immune system (s) in the offspring. Maternal immunization of pregnant mice with T-dependent foreign antigen SRBC induced suppression-of anti-SRBC PFC responses in their offspring. We attempted to identify the cell-species among the maternal lymphoid cells of the immunized pregnant mice that induced this suppression in their offspring, by separating the maternal cells into T-, B-cells and macrophages, or T-cell subsets, and then adoptively transferring them into other normal pregnant mice. The results demonstrated that the maternal CD4^+ T-cells of the immunized pregnant mice induced the immune suppression in their offspring and that the maternal T-cells could be activated uniquely during pregnancy. Furthermore, cellular organization was required for the maternal T-cells to induce this immune suppression in their offspring.