Changes of blood supply after intracanal decompression of the facial nerve

面神经管内减压术后血供变化

• 批准号: 01480407
• 负责人: SAITO Haruo
• 金额: $ 4.16万
• 依托单位: Kochi Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480407/
• 关键词: Facial paraoysis; Hypertonic diuretics; Ischemic paraoysis; Facial nerve decompression; レ-ザ-ドップラ-; 顔面神経血流; 顔面神経; 微小循環; 麻痺; 神経変性; 初期膨化; 障害部位診断

There has been contravergy about the value of surgical decompression in cases of peripheral facial palsy. We have been engaged in researches on tasting and management 'of facial palsy. Outcomes of the surgical intervention with cases of severe facial palsy is not excellent as expected. Supported by the grant, we performed series of experimental and clinical studies. Our previous studies showed that interstitial fluid pressure of the facial nerve totally depended on CSF pressure, and that the interstitial pressure could be reduced by administration of mannitol.We extended the studies to improve treatments of facial palsy.We made an animal model of ischemic facial palsy by interrupting blood flow of the great petrosal aretery. Lesar doppler monitoring of blood flow of the facial nerve showed that decreased blood flow in ischemic facial palsy recovered after administration of mannitol. Histopathological studies of the ischemic facial nerve in guinea pigs showed that interstitial edema decreased after administration of mannitol. Mannitol prevented nerve degeneration of the nerve. Our clinical study also showed that mannitol was effective 'in early cases of Bell's palsy to prevent synkinesis after recovery of mimic movement.There are cases with Bell's palsy which need surgical decompression even with the use of mannitol decompression method.Conventional electrophysiological testings, such as ENOG, are not effective for selecting surgical cases. The site, degree, and recovering phase of the ischemic palsy could be monitored by antidromic facial nerve response in guinea pigs.The authors stress that accurate testing of the facial nerve lesion with antidromic response and early intracanal decompression of the nerve with mannitol is important to improve therapeutic results of facial palsy.

在外周脸麻痹的情况下，关于手术减压的价值存在矛盾。我们一直从事面部麻痹的品尝和管理研究。严重面部麻痹病例的手术干预结果并不是预期的。在赠款的支持下，我们进行了一系列实验和临床研究。我们先前的研究表明，面神经的间质流体压力完全取决于CSF的压力，并且可以通过甘露醇的给药来降低间质压力。我们扩展了研究以改善面部麻痹的治疗方法。我们使缺血性面部麻痹的动物模型通过中断伟大的petrosal saletery arterery的血液流动来中断。莱萨尔多普勒对面神经的血流的监测表明，甘露醇给药后，缺血性面部麻痹的血流减少。豚鼠缺血性面神经的组织病理学研究表明，甘露醇给药后的间质水肿降低。甘露醇阻止了神经的神经变性。我们的临床研究还表明，在贝尔恢复模拟运动后贝尔的麻痹的早期病例中，甘露醇是有效的。有贝尔的麻痹病例，即使使用甘露醇减压方法，也需要手术减压的病例。避孕电生理学测试，例如enog，例如enog，例如eng，无效地选择了有效的病例。缺血性麻痹的部位，程度和恢复阶段可以通过豚鼠中的抗肿瘤的面部神经反应来监测。

项目成果

Kishimoto S.;Nishiyama S.;Furuta M.;Saito H.: "Communicative route between the interstitial space of the facial nerve and CSF space:a hisatopathological study.In “the facial Nerve"" Kugler & Ghedini Publications,Amstelveen, 59-61 (1990)

Kishimoto S.;Nishiyama S.;Furuta M.;Saito H.：“面神经间质空间和脑脊液空间之间的通讯路径：组织病理学研究。在“面神经”中”Kugler & Ghedini Publications，Amstelveen，59 -61 (1990)

Takeda T.;Takeuchi S.;Kishimoto S.;Saito H.: "Interstitial fluid pressure in the facial nerve:Relationship between facial nerve and cerebrospinal fluid pressure." American Journal of Otolaryngology. 10. 345-350 (1989)

Takeda T.；Takeuchi S.；Kishimoto S.；Saito H.：“面神经间质液压力：面神经与脑脊液压力之间的关系。”

Saito H.;Chinzei K: "Facial paralysis of neoplastic Origin.In “The facial Nerve"" Kugler & Ghedini Publications,Amstelveen, 121-123 (1990)

Saito H.；Chinzei K：“肿瘤起源的面瘫。在“面神经”中”Kugler & Ghedini Publications，Amstelveen，121-123 (1990)

Saito H: "Facial nerve to facial canal crossーsectional area ratio in children" Laryngoscope. 102. (1992)

Saito H：“儿童面神经与面管横截面积之比”喉镜 102。（1992）

齋藤 春雄: "末梢性顔面神経麻痺" JOHONS. 5. 49-53 (1989)

Haruo Saito：“周围性面神经麻痹”JOHONS。5. 49-53 (1989)