Effect of Essential Fatty Acid Balance on Symptoms in Various Models for Chronic Disorders.

必需脂肪酸平衡对各种慢性疾病模型症状的影响。

• 批准号: 01480494
• 负责人: OKUYAMA Harumi
• 金额: $ 3.65万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480494/
• 关键词: alpha-Linolenic Acid; Linoleic Acid; Chronic Disease; Cancer; Allergy; Thrombosis; Hypertension; Aging; 必須脂肪質; 学習能; 脳; 食餌; リポフスチン; 過酸化脂質

While linoleic acid is essential for normal growth of animals, alpha-linolenic acid is important for the function of brain and nervous systems. The ratio between alpha-linolenate and linoleate in diets can affect the seriousness of various chronic diseases. Feeding the alpha-linolenic acid-rich diet inhibited the experimental cancer in animal models (mammary tumors, colon carcinoma, pancreatic tumors, pulmonary tumors, prostatic tumors and renal tumors), allergic disorders, thrombotic disorders (myocardial infarct, cerebral infarct and senile dementia), hypertension and cerebral hemorrhage.Dietary enrichment with linoleate relieved symptoms of anti-glomerular basement membrane nephritis. On the other hand, there was no dietary effect on murine autoimmune lupus glomerulo-nephritis in female MRL/1 mice.Endotoxin shock induced by lipopolysaccharide (LPS) combined with galactosamine was inhibited by high-linoleate diet, whereas the hepatitis induced by LPS alone was not affected by the bal … More ance of essential fatty acid in diets. Although there are complicate effects by the balance of alpha-linolenate /linoleate on symptoms of nephritis and endotoxin-shock, it was suggested that eicosanoids derived from linoleate had protective effects on some stage of acute inflammatory disorders.Macrophages from mice fed a high alpha-linolenate diet produced 10-fold more tumor necrosis factor (TNF) in response to LPS stimulation than in a high linoleate diet group. This can be one of the reason for the difference in the essential fatty acid-dependent toxicity by endotoxin-galactosamine. The suppressive effect of alpha-linolenate rich diet on tumorigenesis may be based on this increase of TNF production.Since an alpha-linolenate diet (perilla oil) contains low level of linoleate, feeding a perilla oil diet would affect the generative function. It was shown, however, that there was no significant difference in the duration of pregnancy, delivery intervals, stillbirth rates and embryonic and fetal development, indicating that perilla oil is safe and useful vegetable oil. Less

虽然亚油酸对动物的正常生长至关重要，但α-亚麻酸对大脑和神经系统的功能很重要。饮食中α-亚麻酸和亚油酸的比例可以影响各种慢性疾病的严重性。喂富含α-亚麻酸的饮食可抑制动物模型中的实验性癌症（乳腺肿瘤、结肠癌、胰腺肿瘤、肺肿瘤、前列腺肿瘤和肾肿瘤）、过敏性疾病、血栓性疾病（心肌梗塞、脑梗塞和老年性痴呆）、高血压和脑出血。另一方面，在雌性MRL/1小鼠中，饮食对小鼠自身免疫性狼疮性肾小球肾炎没有影响。高亚油酸饮食可抑制脂多糖（LPS）联合半乳糖胺诱导的内毒素休克，而单用LPS诱导的肝炎则不受高亚油酸饮食的影响。 ...更多信息 必需脂肪酸在饮食中的比例。虽然α-亚麻酸/亚油酸的平衡对肾炎和内毒素休克的症状有复杂的影响，但有人认为亚油酸衍生的类花生酸对急性炎症性疾病的某些阶段具有保护作用。这可能是内毒素-半乳糖胺引起的必需脂肪酸依赖性毒性差异的原因之一。富含α-亚麻酸的饮食对肿瘤发生的抑制作用可能是基于TNF产生的增加。由于α-亚麻酸饮食（紫苏油）含有低水平的亚油酸酯，饲喂紫苏油饮食将影响生殖功能。然而，结果表明，在妊娠期、分娩间隔、死胎率以及胚胎和胎儿发育方面没有显着差异，表明紫苏油是安全和有用的植物油。少

项目成果

Hirose,M.,Masuda,A.,Ito,N.,Kamano,K.,& Okuyama,H.: "Effect of dietary perilla oil,soybean oil and safflower oil on 7,12ーdimethylbenz(a)anthracene (DMBA) and 1,2ーdimethylhydrazone (DMH)ーinduced mammary gland andーーーーー." Carcinogenesis. 11. 731-735 (1990)

Hirose, M.、Masuda, A.、Ito, N.、Kamano, K. 和 Okuyama, H.：“膳食紫苏油、大豆油和红花油对 7,12-二甲基苯并（a）蒽 (DMBA) 的影响) ) 和 1,2-二甲基腙 (DMH) 诱导的乳腺和……”致癌作用。11. 731-735 (1990)

Hirose, M., Masuda, A., Ito, N., Kamano, K. and Okuyama, H.: "Effect of dietary perilla oil, soybean oil and safflower oil on 7, 12-dimethylbenz(a)anthracene (DMBA) and 1, 2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesis in female

Hirose, M.、Masuda, A.、Ito, N.、Kamano, K. 和 Okuyama, H.：“膳食紫苏油、大豆油和红花油对 7, 12-二甲基苯并（a）蒽 (DMBA) 的影响

N.Yamamoto,Y.Okaniwa et al: "Effects of a high-linoleate and a high-α-linolenate diets on the learning ability" J.Gerontol.(1990)

N. Yamamoto、Y. Okaniwa 等人：“高亚油酸和高 α-亚麻酸饮食对学习能力的影响”J. Gerontol (1990)。

Watanabe,S.,Suzuki,E.,Kojima,R.,Suzuki,R.,& Okuyama,H.: "Effect of dietary αーlinolenate/linoleate balance on crescenetーtype antiーglomerular basement membrane nephritis in rats." Lipids. 25. 267-272 (1990)

Watanabe, S.、Suzuki, E.、Kojima, R.、Suzuki, R. 和 Okuyama, H.：“膳食 α-亚麻酸/亚油酸平衡对大鼠新月形抗肾小球基底膜肾炎的影响”。脂质。25。267-272（1990）

Watanabe,S.,Hayashi,H.,Onozaki,K.,& Okuyama,H.: "Effect of dietary αーlinolenate/linoleate balance on lipopolysaccharideーinduced tumor necrosis factor production in mouse macrophages." Life Sci.in-press (1991)

Watanabe, S.、Hayashi, H.、Onozaki, K. 和 Okuyama, H.：“膳食 α-亚麻酸/亚油酸平衡对小鼠巨噬细胞中脂多糖诱导的肿瘤坏死因子产生的影响。” (1991)