禁煙・禁酒後の血中過酸化脂質と脂溶性抗酸化ビタミン類(A,E,βカロチン)の推移

戒烟戒酒后血液过氧化脂质和脂溶性抗氧化维生素（A、E、β-胡萝卜素）的变化

• 批准号: 02454210
• 负责人: 豊嶋 英明
• 金额: --
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454210/
• 关键词: 禁煙・禁酒; βカロチン; 過酸化脂質; レチノ-ル; トコフェロ-ル; 経時変化

禁煙・禁酒により血中のβカロチン(単位μg/dl)、レチノ-ル(同)、トコフェロ-ル(同)、過酸化脂質(nmol/ml)濃度がたどる経時的変化を知るために、喫煙、飲酒習慣を持つ20〜33歳の健康男子24名を禁煙群(7名)、禁酒群(2名)、禁煙・禁酒群(8名)、喫煙・飲酒を継続する群(7名)に割り付け、実行開始後2週、4週目、並びに解除後4週目に於けるこれらの測定値を群間で比較した。対照群に両習慣の無い者7名を設定した。βカロチンについては摂取量の影響を考慮するため、連続2日間の摂取量を実行開始前と、4週後に調査した。実行開始前では、対照群のβカロチン濃度の平均値31.5±16.4に比べ、両習慣のある24名の平均値11.7±6.8は有意(P<0.05)に低く、各群別では禁煙群の15.4は低めであり、禁酒群の5.1と禁煙・禁酒群の12.2、並びに継続群の9.4は有意に低かった(一元配置分散分析P<0.005,Scheffeの級間比較P<0.05)。実行開始4週後には禁煙群、禁酒群、禁煙・禁酒群のβカロチンの平均濃度は最も高い値を示し、解除後4週目では減少した。この時間変化は有意であったが、継続群では有意な時間変化を示さなかった。(一元配置分散分析と級間比較)。禁煙禁酒実行群全体(17名)と継続群の開始前でのβカロチン平均濃度は各々12.7±7.0と9.4±6.2で有意差はなく、4週後では29.9±15.4と16.0±13.0で有意差を認めた。βカロチン摂取量と血清濃度の間、並びに各々の変化量の間には有意な相関は認められなかった。過酸化脂質濃度の平均値は喫煙・飲酒習慣の無い群では2.5±0.5,両習慣のある群では2.9±0.7であり両群間には有意差は無く、又、継続群、実行群ともに有意な時間変化を示さなかった。レチノ-ル、トコフェロ-ル濃度も対照群と喫煙飲酒群、並びに継続群と実行群の間で有意差は認められなかった。以上より、禁煙、禁酒によりβカロチン濃度においてのみ上昇傾向が認められた。

The levels of β-lactic acid in blood (μ g/dl), alcohol (n = 2), alcohol (n = 8), over-acidified fat (nmol/ml) in the blood of 24 healthy men (n = 7), alcohol group (n = 2), alcohol group (n = 8), alcohol group (n = 2), alcohol group (n = 7), alcohol group (n = 2), alcohol group (n = 8), alcohol group (n = 8), alcohol group (n = 7), alcohol group (n = 2), alcohol group (n = 8), alcohol group (n = 7), alcohol group (n = 2), alcohol group (n = 8), alcohol group (n = 8), alcohol group (n = 7), alcohol group (n = 2), alcohol group (n = 8), alcohol group (n = 8), alcohol group (n = 7), alcohol group (n = 2), alcohol group (n = 8), alcohol group (n = 8), alcohol group ( There are 7 people in the market group (7). The payment is 2 years, 4 years after the opening, and 4 years after the opening of the bank. There are 7 users who are free to set the license according to the group license. The value of the β-ray measurement system will be measured in the first two days before the start of the operation, and four days later. Before the start of the trip, there was an average of 31. 5 ±16. 4 per cent in the pre-and post-trip group, and an average of 11. 7 ±6. 8 per cent in 24 residents (P&lt) 0.05) low alcohol consumption, 15.4 per group prohibition, 5.1 prohibition, 12.2 prohibition, and 9.4 intentional low consumption (univariate configuration dispersion analysis, 0.005 Scheffe, 0.05). Four weeks after the start of the operation, the average temperature of the prohibition group, the prohibition group and the prohibition group was the highest, and the average temperature of the prohibition group was lower than that of the control group. When you want to change your time, you can use your time to show that you are interested in making sure that you are busy. (univariate configuration dispersion analysis inter-cluster comparison). There were 17 students in the prohibition group (n = 17). Before the start of the group, the average degrees of β-rays were 12.7 ±7.09.4 ±6.2 and 29.9 ±15.4 ±16.0 ±13.0 respectively. The concentration of β-lactamase was measured between serum levels, and the concentrations of different concentrations were measured in order to determine the concentration of serum. The average temperature of acidified fat is 2.5 ±0.5, that of alcohol is 2.5 ±0.5, that of alcohol is 2.9 ±0.7, that of customers is 2.9 ±0.7, and that of customers and customers is intentional. In the light of the temperature, the wine group, the wine group and the wine group. The above, prohibition, prohibition and prohibition.

项目成果

豊嶋 英明: "禁煙・禁酒後の血中過酸化脂質と脂溶性ビタミン類(A,E,βカロチン)の推移" 日本衛生学雑誌.

Hideaki Toyoshima：“戒烟戒酒后血液过氧化脂质和脂溶性维生素（A、E、β-胡萝卜素）的变化”日本卫生杂志。