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Induction of ovulation with pulsatile subcutaneous administration of menopausal gonadotropin in anovulatory infertile women.

对无排卵不孕女性进行绝经期促性腺激素脉动皮下注射诱导排卵。

基本信息

批准号：
02454388
负责人：
NAKAMURA Yukio
金额：
$ 1.22万
依托单位：
Kyorin University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

The pulsatile subcutaneous administration of human menopausal gonadotropin (hMG) was used for induction of ovulation in patients with anovulatory infertile women. Ovulation was observed in 90.6% of 128 treatment cycles, and 16 (18 treatment cycles) of 26 patients became pregnant. All 16 fetus, excluding two pregnancies interrupted spontaneously, were sigleton conceptions. Ovarian hyperstimulation was observed in 15.6% of treatment cycles. In the second experiment, treatment with a combination of gonadotropin releasing hormone agonist (GnRHa) and pulsatile administration of hMG was used to induce ovulation in patients with polycystic ovary syndrome (PCO). GnRHa administration, permit manipulation and alteration of the levels of LH and FSH, resulting in normalization of the LH/FSH ratio. This may lessen the risk of ovarian hyperstimulation. The final experiment was undertaken to assess the clinical relevance of daily hormonal changes for achieving a successful pregnancy in anovulatory in … More fertile women. Up to the mid-luteal phase progesterone (P) and estradiol (E_2) values in non-pregnant cycles did not differ significantly from those in pregnant cycles. However, the P/E_2 ratio in the mid-luteal phase was significantly greater in pregnant cycles than in the non-pregnant cycles, suggesting that the P/E_2 ratio is a more important indicator of hormonal function for implantation than the absolute levels of either P or E_2. A premature endogenous LH rise and premature luteinization were frequent phenomena in anovulatory infertile women undergoing the pulsatile administration of hMG. However, the incidences in the pregnant cycles were comparable to those in non-pregnant cycles, suggesting that the occurrence of premature luteinization may not necessarily be detrimental to the establishment of successful pregnancy.The present study demonstrate that pulsatile subcutaneous administration of hMG is effective in induction of successful ovulation and establishment of singleton pregnancy in patients with anovulatory infertility. Less

人类绝经期促性腺激素（hMG）皮下脉冲给药用于诱导无排卵不孕妇女的排卵。在128个治疗周期中，90.6%的患者排卵，26例患者中有16例（18个治疗周期）怀孕。除2例自然中断妊娠外，所有16例胎儿均为单胎妊娠。15.6%的治疗周期出现卵巢过度刺激。实验二采用促性腺激素释放激素激动剂（GnRHa）联合脉动给药hMG的方法诱导多囊卵巢综合征（PCO）患者排卵。GnRHa管理，允许操纵和改变LH和FSH水平，导致LH/FSH比率正常化。这可能会降低卵巢过度刺激的风险。最后的实验是为了评估每日激素变化对实现无排卵成功怀孕的临床意义。直到黄体中期，非妊娠周期的黄体酮(P)和雌二醇（E_2）值与妊娠周期的黄体酮(P)和雌二醇（E_2）值无显著差异。然而，妊娠周期中黄体中期P/E_2比值明显高于非妊娠周期，提示P/E_2比值比P或E_2的绝对水平更重要的激素功能指标。内源性黄体生成素的过早升高和黄体生成素的过早形成是无排卵性不孕症妇女脉动服用hMG的常见现象。然而，妊娠周期的发生率与非妊娠周期的发生率相当，这表明黄体早衰的发生不一定对成功妊娠的建立有害。目前的研究表明，搏动皮下给药hMG是有效的诱导成功排卵和建立单胎妊娠无排卵不孕症患者。少

项目成果

期刊论文数量（56）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

中村幸雄他: "ゴナドトロピン療法" 産科と婦人科. 57. 400-402 (1990)

Yukio Nakamura 等人：“促性腺激素疗法”妇产科 57. 400-402 (1990)。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

中村幸雄他: "hMG律動的皮下投与周期および自然排卵周期における着床、非着床周期のホルモン動態" 日本受精着床学会誌. 8. 63-66 (1991)

Yukio Nakamura 等人：“hMG 节律性皮下注射周期和自然排卵周期中植入和非植入周期的激素动态”日本受精和植入学会杂志 (Journal of the Japanese Society of Fertilization and Implantation) 8. 63-66 (1991)。