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Studies of Conservation Treatments of Head and Neck Cancer and Posttherapeutic Quality of Life

头颈癌的保守治疗和治疗后生活质量的研究

基本信息

批准号：
02454399
负责人：
HIRANO Minoru
金额：
$ 4.42万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454399/
关键词：
Head and Neck Cancer Laryngeal Cancer Oral Cancer Oropharynx Cancer Hypopharynx Cancer Maxillary Sinus Cancer Quality of Life Conservation Treatment 機能保存治療咽頭癌頭頚部癌 qualty of life

项目摘要

1) Histopathological Studies. Surgical specimens of 80 cases with laryngeal cancer, 60 cases with oral cancer, 50 cases with hypopharynx cancer, 36 cases of maxillary sinus cancer were histopathologically investigated. As for laryngeal cancer, mechanisms of vocal fold fixation were histopathologically determined. For oral cancer, relationships among the diameter and depth of lesion, subepithelial extension and cervical metastasis were determined. As for hypopharynx cancer, patient selection for conservation surgery was investigated from a histopathological viewpoint and the relevance of computed tomography was determined. In the cases with maxillary sinus cancer, the histologically evaluated effect of preoperative local chemotherapy and radiotherapy was related to the rate of recurrence.2) Studies on Posttherapeutic Functions. The vocal function was investigated in 27 patients following laser cordectomy. The respiratory, phonatory and swallowing function were determined in 64 hemilaryngectomy cases and 38 supraglottic laryngectomy cases. As for hypopharynx cancer, swallowing function was related to reconstruction techniques in 22 conservation surgery cases and 26 laryngopharyngectomy cases. The articulatory function was related to the degree of surgical intervention in 74 cases with oral cancer and 20 cases with oropharynx cancer, and the swallowing function, in 88 patients with oral cancer and 66 with oropharynx cancer.3) Studies for Treatment Modalities. For the purpose to improve the posttherapeutic quality of life, several techniques of laser surgery, reconstructive surgeries and rehabilitation were developed, investigated and evaluated.4) Report of Investigations. A booklet to report the result of the 3-year studies is being published.

1)历史学研究。对80例喉癌、60例口腔癌、50例下咽癌、36例上颌窦癌手术标本进行组织病理学观察。至于喉癌，声带固定的机制是组织病理学确定的。对于口腔癌，确定病变直径和深度、上皮下延伸和颈部转移之间的关系。至于下咽癌，从组织病理学的角度研究了保留手术的患者选择，并确定了计算机断层扫描的相关性。上颌窦癌患者术前局部化疗和放疗的组织学评价与复发率有关。2）术后功能研究。对27例激光声带切除术后的发音功能进行了观察。对64例半喉切除术和38例声门上喉切除术患者的呼吸、发音和吞咽功能进行了测定。下咽癌保留手术22例，喉咽切除术26例，吞咽功能与重建技术有关。74例口腔癌和20例口咽癌患者的发音功能与手术干预程度有关，88例口腔癌和66例口咽癌患者的吞咽功能与手术干预程度有关。为了提高治疗后的生活质量，开发了几种激光手术，重建手术和康复技术，并进行了调查和评估。目前正在出版一本小册子，报告三年研究的结果。