Clinical research for Visual disturbance in Multi infarct denentia

多发性梗塞性痴呆视觉障碍的临床研究

• 批准号: 02454400
• 负责人: KIYOSAWA Motohiro
• 金额: $ 4.35万
• 依托单位: Tohoku Unviersity
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454400/
• 关键词: positron emission tomography; cerebral metabolic rate for glucose; cerebral blood flow; cerebral infarction; Seuile dementia; Multi infarct dementia; Alzheimcrs disease; Cerebral mefabolism; 脳血流量; 視覚失認; ポジトロンエミツショントモグラフィ-; 視覚障害

Abstract Cerebral metabolic rate for glucose (CMRGlc) of twelve patients with multi-infarct dementia (MID) as well as agematched controls were evaluated with positron emission tomography and F18-fluoro-deoxyglucose technique. Primary visual function (visual acuity), as well as higher visual function (color vision, stereopsis, and figure copying) were also evaluated. We found that all the MID patients showed impaired higher visual function and CMRGlc of the primary as well as the associate visual cortices of the patients were lower than those of the controls, and that CMRGlc of the primary visual cortices of the patients with impaired visual acuity was lower than that of the patients with unimpaired visual acuity, whereas CMRGlc of the associate visual cortices was not different. Dementing process may directly affects metabolism and function in the associate cortices.

摘要采用正电子发射断层扫描和f18 -氟脱氧葡萄糖技术对12例多发性梗死性痴呆（MID）患者及年龄匹配对照组的脑葡萄糖代谢率（CMRGlc）进行了测定。初级视觉功能（视敏度）和高级视觉功能（色觉、立体感和图形复制）也进行了评估。我们发现，所有MID患者均表现为高级视觉功能受损，患者的初级和副视皮质CMRGlc均低于对照组，视力受损患者的初级视觉皮质CMRGlc低于视力未受损患者，而副视皮质CMRGlc无差异。痴呆过程可能直接影响相关皮质的代谢和功能。

项目成果

Bosley TM.,Kiyosawa M et.al: "Neuro-imaging and Positron Emission tomography of Congenital homonymous hemiavopia" Am.J.Ophthalmol.111. 413-418 (1991)

Bosley TM.、Kiyosawa M 等人：“先天性同名偏侧视的神经成像和正电子发射断层扫描”Am.J.Ophthalmol.111。

M.Kiyosawa,TM Bosley: "Middle cerelral artery strokes causing homonymus henianopia:Positron emission tomography" Ann.Neurol. 28. 180-183 (1990)

M.Kiyosawa，TM Bosley：“大脑中动脉中风导致同名盲症：正电子发射断层扫描”Ann.Neurol。

M. Kiyosawa, T. M. Bosley, M. Kushner, D. Jamieson, A. Alavi and M. Reivich: "Middle cerebral artery strokes causing homonymous hemianopia : Positron emission tomography" Ann Neurol. 28. 180, 183 (1990)

M. Kiyosawa、T. M. Bosley、M. Kushner、D. Jamieson、A. Alavi 和 M. Reivich：“大脑中动脉中风导致同向偏盲：正电子发射断层扫描”Ann Neurol。

Bosley TM, Kiyosawa M. Moster M. Harbour R, Zimmerman R, Savino PJ, Sergott RC, Alavi A, Reivich M.: "Neuro-imaging and Positron emission tomography of congenital homonymous hemianopia" Am. J. Ophthalmol. 111. 413-418 (1991)

Bosley TM、Kiyosawa M. Moster M. Harbor R、Zimmerman R、Savino PJ、Sergott RC、Alavi A、Reivich M.：“先天性同向偏盲的神经成像和正电子发射断层扫描”Am。

Meguro K.,kiyosawa M et al.: "Decreased glucose metabolism in visual cortices associated with impaired visual functions in patients with multi infarct Pementid." J.neuro imaging.

Meguro K.、kiyosawa M 等人：“视觉皮层葡萄糖代谢降低与多发性梗塞性脑膜炎患者视觉功能受损相关。”