Clinical research for Visual disturbance in Multi infarct denentia

应用正电子发射断层扫描（PET）和氟脱氧葡萄糖（F18）技术，对12例多发梗塞性痴呆（MID）患者及年龄匹配的对照组进行了脑葡萄糖代谢率（CMRGlc）的测定。还评估了初级视觉功能（视力）以及高级视觉功能（色觉、立体视觉和图形复制）。结果发现，MID患者均表现为高度视功能受损，其初级视皮层和副视皮层的CMRGlc均低于正常对照组，视力受损者初级视皮层的CMRGlc低于视力正常者，而副视皮层的CMRGlc无差异。痴呆过程可能直接影响相关皮质的代谢和功能。

Abstract Cerebral metabolic rate for glucose (CMRGlc) of twelve patients with multi-infarct dementia (MID) as well as agematched controls were evaluated with positron emission tomography and F18-fluoro-deoxyglucose technique. Primary visual function (visual acuity), as well as higher visual function (color vision, stereopsis, and figure copying) were also evaluated. We found that all the MID patients showed impaired higher visual function and CMRGlc of the primary as well as the associate visual cortices of the patients were lower than those of the controls, and that CMRGlc of the primary visual cortices of the patients with impaired visual acuity was lower than that of the patients with unimpaired visual acuity, whereas CMRGlc of the associate visual cortices was not different. Dementing process may directly affects metabolism and function in the associate cortices.