Correlation between optic nerve projection changes and neural functional plasticity, following to damage in anteriorvisual pathuazs.

目的：观察出生后第10天（PN10）单眼去核或眼睑缝合后大鼠脑视觉中枢腺苷A_1、苯二氮卓受体密度及糖代谢的变化。方法：对PN10大鼠进行单眼去核或双眼缝合后，分别用[^<11>C]MPDX、[^<11>C]氟马西尼和[^<14>C]2-脱氧葡萄糖进行体外放射自显影，观察上丘（SC）、背外侧膝状体（DLG）和视觉皮层（VC）腺苷A_1、苯二氮平受体密度和葡萄糖代谢的变化。结果：去核降低了SC和DLG中[^<11>C]MPDX结合，增强了SC中[^<11>C]氟马西尼结合，眼睑缝合降低了VC中[^<11>C]氟马西尼结合。[^<14>C]除SC和DLG外，在第1天，除SC和DLG外，任何区域的2-脱氧葡萄糖摄取均未因去核而减少，但在第20天和第55天，SC和第55天，眼睑缝合后，2-脱氧葡萄糖摄取减少。结论：去核后SC和DLG突触前腺苷A_1受体的减少与突触后苯二氮卓类受体的上调有关。大鼠视觉功能神经结构的发育在PN10期尚未完成。眼睑去核后的神经反应与眼睑缝合后的神经反应完全不同。

Purpose : To determine the changes in the densities of adenosine A_1, and benzodiazepine receptors densities and in glucose metabolism in the visual centers of rat brain following monocular enucleation or eyelid suture on postnatal day 10 (PN10). Methods : Following monocular enucleation or eyelid suture on PN10 rats, the alterations in the adenosine A_1, and benzodiazepine receptor densities and in glucose metabolism were evaluated in superior colliculus (SC), dorsal lateral geniculate body (DLG), and visual cortex (VC) by ex vivo autoradiography with [^<11>C]MPDX, [^<11>C]flumazenil and[^<14>C]2-deoxyglucose, respectively. Results : Enucleation reduced the [^<11>C]MPDX binding in SC and DLG, and enhanced the [^<11>C]flumazenil binding in SC. Eyelid suture reduced the [^<11>C]flumazenil binding in VC at day 20. [^<14>C]2-deoxyglucose uptake was not decreased by enucleation in any region except in SC and DLG at day 1, but was decreased by eyelid suture in SC at day 20 and 55 and in VC at day 55. Conclusions : The decrease in the presynaptic adenosine A_1, receptors in SC and DLG following enucleation is coupled with an up-regulation of postsynaptic beuzodiazepine receptors. The development of neural architecture for visual functions is not completed at PN10 in rats. Neural reactions following enucleation are completely different from those following eyelid suture.