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Experimental studies on successive changes of the microvascular architecture during the period of bone healing the dental implantation

种植牙骨愈合过程中微血管结构连续变化的实验研究

基本信息

批准号：
02454452
负责人：
OHTA Yoshikuni
金额：
$ 4.03万
依托单位：
Osaka Dentral University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

In other to elucidate bio-compatibility of the dental materials, successive changes of the microvascular architecture which contributes to form supporting tissues, especially bone tissue, have been investigated utilizing the acryl plastic injection method (Ohta et al., 1952, 1955, 1990) for a scanning electron microscopy.Materials and methods : Implant operations were performed by the primary, secondary and immediate procedures on the upper incisor and lower molar regions of Japanese monkeys. Implant materials used for this study were titanium, hydroxyapatite (HAP), HAP・alumina-coated Ti (cylinder, blade-vent), alumina-ceramics (notched, pored, blade), etc. Three-dimensional specimens mounted with both microvascular corrosions and bone tissue, and histological slides, were prepared ranging from immediate to 10 weeks after implantation and examined under a scanning electron microscope (JEOL JSM- T300).Results : Generally, an initial extension of newly formed sinusoidal capillaries was f … More ound on the implantal interface two weeks after implantation. Each of new bone tissues appearing in the shape of an island have developed to a wide plate up to four weeks. Outside it a capillary cylinder was located between the preexistant and newly formed bones. However, when a perimplantal space was exsistant, a characteristic bone trabeculae spread from the preexistant bone with newly-formed sinusoids and proliferated to complete a final osseous integration. On the HAP interface, a new bone tissue appears in a peculiar form (ankylosis) differing from the above trabeculae. A pore of the alumina ceramics has been invaded by a new sinusoidal capillary two weeks but scarcely filled up all pores yet. It can be concluded that periods of two to four weeks after implantation are an important and significant to form a newly-formed woven bone, the beginning of which is found at a limited area of the implant interface, such as notch, screw and vent, always accompanying with the sinusoidal capillary. For the present, influences on surrounding structures of the already-fixed implant have continuously investigated under various occlusal conditions. Less

为了阐明牙科材料的生物相容性，已经利用丙烯酸塑料注射方法研究了有助于形成支持组织，特别是骨组织的微血管结构的连续变化（Ohta等人，材料和方法：在日本猴的上切牙和下磨牙区域通过初次、二次和即刻手术进行种植手术。本研究使用的植入物材料为钛、羟基磷灰石（HAP）、HAP·氧化铝涂层钛（气缸，叶片通风口），氧化铝陶瓷在植入后即刻至10周，制备固定有微血管腐蚀和骨组织的三维标本以及组织学切片，并在扫描电子显微镜下进行检查结果：新生窦状隙毛细血管的初始延伸一般为1.5 ~ 1.5 cm，新生窦状隙毛细血管的初始延伸一般为1.5 ~ 1.5 cm，新生窦状隙毛细血管的初始延伸一般为1.5 ~ 1.5 cm，新生窦状隙毛细血管的初始延伸一般为1.5 ~ 1.5 cm。 ...更多信息植入后两周在骨界面上发出声音。每一个新的骨组织出现在一个岛屿的形状已经发展到一个广泛的板长达四周。在它的外面，一个毛细管柱位于先存骨和新形成的骨之间。当周围间隙存在时，特征性的骨小梁从先存骨中以新形成的血窦扩展并增殖，最终完成骨整合。在HAP界面上，新的骨组织以不同于上述骨小梁的特殊形式（强直）出现。氧化铝陶瓷的一个孔隙已被一个新的正弦毛细管侵入两周，但几乎没有填满所有的孔隙。结果表明，种植体植入后2 ~ 4周是形成新编织骨的重要时期，新编织骨的形成起始于种植体界面的有限区域，如缺口、螺钉和通气孔，并伴有窦状毛细血管。目前，已经固定的种植体在各种咬合条件下对周围结构的影响一直在研究中。少