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Regulatory role of vasopressin in the function of the central nervous system.

加压素对中枢神经系统功能的调节作用。

基本信息

批准号：
02454512
负责人：
SAITO Toshikazu
金额：
$ 4.29万
依托单位：
Jichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

Some stressful stimuli increase the release or the production of arginine-vasopressin (AVP). It is suggested that AVP acts on the central nervous system as a neuromodulator or a neurotransmitter unter some stressful conditions. To clarify the role of AVP in a series of changes induced by stress, we examined the differences between AVP-deficient animals and control animals in the responses to stress.Hereditary hypothalamic diabetes insipidus rat of Brattleboro strain (DI) was more susceptible to gastric ulcer induced by restraint and water immersion than Long-Evans rat (LE). Intracerebroventricular (ICV) administration of AVP reduced gastric lesions in DI and ICV administration of AVP V_1-receptor antagonist increased gastric lesions. In DI, plasma responses of ACTH and catecholamine to stress were attenuated and ICV administration of AVP enhanced them. ICV administration of V_1-antagonist reduced plasma responses of ACTH and catecholamine in LE.Furthermore, we study the role of AVP in stress-induced elevation of blood pressure using spontaneously hypertensive rat (SHR) with a partial defect in AVP production. In SHR with partial AVP defect, sustained elevation of blood pressure by chronic stress, which was observed in SHR, was not provocated.These results suggest that central AVP plays not only a suppressive role in the development of gastric ulcer but also a stimulating role in the elevation of blood pressure and responses of plasma ACTH and catecholamine induced by stress.

一些应激刺激增加精氨酸加压素（AVP）的释放或产生。提示AVP在某些应激状态下可作为神经调质或神经递质发挥作用。为了阐明AVP在应激引起的一系列变化中的作用，我们研究了AVP缺陷动物和对照动物对应激反应的差异，发现Brattleboro系遗传性下丘脑尿崩症大鼠（DI）比Long-Evans大鼠（LE）更易发生束缚和水浸引起的胃溃疡。侧脑室注射AVP可减轻DI时胃粘膜损伤，而侧脑室注射AVP V_1受体拮抗剂可加重DI时胃粘膜损伤。在DI中，血浆促肾上腺皮质激素和儿茶酚胺对应激的反应减弱，ICV给予AVP增强了这些反应。脑室注射V_1受体拮抗剂（ICV）可降低LE血浆ACTH和儿茶酚胺的反应性，并以AVP产生部分缺陷的自发性高血压大鼠（SHR）为模型，研究AVP在应激性血压升高中的作用。在AVP部分缺失的SHR中，慢性应激引起的血压持续升高并没有被激发，提示中枢AVP不仅在胃溃疡的发生发展中起抑制作用，而且在应激引起的血压升高和血浆ACTH、儿茶酚胺反应中起刺激作用。