Cell-type specific signal processing in the medial entorhinal cortex deep layer micronetwork

内侧内嗅皮层深层微网络中的细胞类型特异性信号处理

• 批准号: 430282670
• 负责人: Dr. Alexei Egorov
• 金额: --
• 依托单位: Institut für Physiologie und Pathophysiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/430282670?language=en
• 关键词: Cell; type; specific; signal; processing

Small neuronal networks express multi-neuronal activity patterns which are likely forming elementary representations. Typically, any complex cognitive or behavioral activity involves multiple local networks which are activated either simultaneously or sequentially. For some sensory and motor systems, there is considerable knowledge about the specific information contained in the activity of different local circuits. This is, however, much less clear for higher cognitive functions like spatial memory formation. Representations of spatial experiences are formed in the entorhinal-hippocampal formation. In the hippocampus they take the form of sharp wave-ripple complexes (SPW-R), which propagate into neocortical networks for long-term memory consolidation. The underlying mechanisms remain largely enigmatic. We want to study the first step in this chain of events, namely the propagation of SPW-R from the hippocampus to the medial entorhinal cortex (mEC) of mice. Our previous work shows that incoming hippocampal SPW-R activate two anatomically and functionally distinct sub-networks within mEC layer V. These parallel streams of activity are governed by two different sets of principal cells which form distinct intracortical micro-networks. We want to untangle the underlying connectivity and synaptic mechanisms, characterize the resulting multi-neuronal activity patterns and elucidate the role of inhibitory interneurons in structuring and separating the distinct pathways. Our work shall reveal basic mechanisms of a key example of segregated information processing in cortical networks.

小的神经元网络表达多神经元的活动模式，这些模式很可能形成初级表征。通常，任何复杂的认知或行为活动都涉及多个同时或顺序激活的局部网络。对于一些感觉和运动系统，有相当多的关于不同局部电路活动中包含的特定信息的知识。然而，对于空间记忆形成等高级认知功能来说，这一点就不那么清楚了。空间体验的表征是在内嗅-海马区形成的。在海马体中，它们以尖锐波纹复合体（SPW-R）的形式传播到新皮层网络，以巩固长期记忆。其潜在机制在很大程度上仍是个谜。我们想要研究这一系列事件的第一步，即SPW-R从小鼠海马到内侧内嗅皮层（mEC）的传播。我们之前的工作表明，进入海马的SPW-R激活了mEC层v内两个解剖学和功能上不同的子网络。这些平行的活动流由两组不同的主细胞控制，这些主细胞形成不同的皮层内微网络。我们希望解开潜在的连通性和突触机制，表征由此产生的多神经元活动模式，并阐明抑制性中间神经元在构建和分离不同通路中的作用。我们的工作将揭示皮质网络中分离信息处理的一个关键例子的基本机制。