Studies on protection of progression of renal impairment.

保护肾功能损害进展的研究。

基本信息

批准号：
03454221
负责人：
SARUTA Takao
金额：
$ 3.2万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454221/
关键词：
hypertension renal impairment salt protein Calcium Ca channel blocker ACE inhibitor 降圧薬腎不全

项目摘要

Diet and blood pressure are important in the control of renal function in various renal diseases. Until now it has been made clear that appropriate restriction of salt and protein is effective in patients with renal impairment, but it is unknown that calcium(Ca) supplementation is useful for those patients. Furhtermore it is still controversial how much hypertension is harmful in pateints with renal impairment. In this study the effects of diet and antihypertensive drugs on renal function and blood pressure were studied in animal experiments and in patients with renal impairment.In the first animal experiment using DOCA-salt adriamycin treated rats, oral Ca supplementation ameliolated a part of chronic progression of renal damage by phosphate binding action. In the second animal experiment using 5/6 nephrectomized salt loaded spontaneously hypertensive rats, effects of various antihypertensive drugs on renal function and hypertension were studied. In this study it was demonstrated that … More an angiotensin converting enzyme(ACE) inhibitor and a Ca channel blocker are more effective than a diuretic to the progression of renal impairment and renal histological changes. However, there were no significact differences between the ACE inhibitor and the Ca channel blocker, although the Ca channel blocker didn't dilate the efferent arteriole different from the ACE inhibitor.In hypertensive patients with renal impairment 2 types of Ca channel blockers were demonstrated to be effective in the control of hypertension and renal function Ca channel blockers seemed to be safer than ACE inhibitors in patients with advance renal damage showing serum creatinine over 2 mg/dl.From these studies it was suggested that Ca supplementation in addition to salt and protein restriction is effective for prevention of renal impairment, and Ca channel blockers are also effective in the control of hypertension and renal function as well as ACE inhibitors, although the mechanims of action of Ca channel blockers were supposed to be different from that of ACE inhibitors. Less

饮食和血压对于控制各种肾脏疾病的肾功能很重要。到目前为止，已经明确表明，盐和蛋白质的适当限制对于肾脏损伤患者有效，但尚不清楚钙（CA）补充对这些患者有用。 Furhtermore仍然有争议的高血压在肾脏损害的补丁中有害。在这项研究中，在动物实验和肾功能障碍的患者中研究了饮食和降压药对肾功能和血压的影响。在使用Doca-salt adriamycin治疗的大鼠进行的第一个动物实验中，口服CA补充剂补充磷酸盐结合动作促进肾脏损害的一部分。在第二次动物实验中，研究了各种抗高血压药物对肾功能和高血压的影响，使用了5/6肾切除盐的盐分。在这项研究中，证明……更多的血管紧张素转化酶（ACE）抑制剂和CA通道阻滞剂比利尿剂更有效，对肾脏损伤和肾脏组织学变化的进展。然而，ACE抑制剂和CA通道阻滞剂之间没有显着差异，尽管CA通道阻滞剂没有扩张与ACE抑制剂不同的有效动脉抑制剂。在肾脏损伤的高血压患者中，两种CA通道阻滞剂的高血压患者被证明在高度损害的CA频道障碍中有效，与肾脏功能相比，与肾脏的损害相比，与肾脏的损害相比，在肾脏中损害了两名，而在肾脏中的损害似乎是更安全的。 Mg/dl。从这些研究中提出，除了盐和蛋白质限制外，补充CA可有效预防肾脏损伤，CA通道阻滞剂也可以有效地控制高血压和肾功能以及ACE抑制剂，尽管CA通道阻滞剂的作用机制与ACE抑制剂的作用机制不同。较少的