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STUDIES ON THE INCIDENCE AND MECHANISM OF HYPERTENSION IN HEMI-NEPHRECTOMIZED SUBJECTS.

半侧肾切除受试者高血压的发生率和机制的研究。

基本信息

批准号：
60570300
负责人：
SARUTA Takao
金额：
$ 1.15万
依托单位：
The Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570300/
关键词：
Hemi-nephrectomy Hypertension Sodium The remaining kidney 腎機能

项目摘要

It is supposed that hypertension develops easily in hemi-nephrectomized subjects. However, the real incidence of the hypertension is obscure and its mechanism is still unknown. In this study it was investigated how often hypertension develops after hemi-nephrectomy, and the mechanism of hypertension was examined in man and rats.In human study using 34 subjects in which hemi-nephrectomy was done more than 3 years ago, hypertension over 160 mmHg systolic and 95 mmHg diastolic was observed in 17 of 34 subjects (50%). In those subjects with hypertension, renal function was more reduced than that in the subjects without hypertension. The causes of hemi-nephrectomy also seemed to be related to the frequency of the development of hypertension, since its frequency seemed to be more often in patients in whom the remaining kidney was supposed to be damaged by some diseases. Urinary excretion of kallikrein was markedly reduced in the hemi-nephrectomized subjects, but it was not clear whether its reduction may play an important role in the development of hypertension.In animal study, development of hypertension was more frequent when hemi-nephrectomy was done in rats weighing 350-360 g than when it was done in rats weighing 140-150 g. It was also found that overloading of salt beyond excretory function seems to be important, since development of hypertension was accelerated by sodium loading.From these studies it was suggested that hypertension develops easily in hemi-nephrectomized subjects, probably due to limited excretory function, in which the compensatory function of the remaining kidney may play an important role.

据推测，高血压在半肾切除的受试者中容易发生。然而，高血压的真实的发病率尚不清楚，其发病机制尚不清楚。在本研究中，调查了半肾切除术后高血压发生的频率，并在人和大鼠中检查了高血压的机制。在对34名在3年前进行半肾切除术的受试者进行的人体研究中，在34名受试者中有17名（50%）观察到收缩压超过160 mmHg，舒张压超过95 mmHg。高血压组肾功能下降程度较非高血压组明显。半肾切除术的原因似乎也与高血压的发生频率有关，因为其发生频率似乎更常见于剩余肾脏被认为受到某些疾病损害的患者。在动物实验中，体重350-360 g的大鼠行半肾切除术后，高血压的发生率明显高于体重140-150 g的大鼠。此外，还发现盐负荷超过排泄功能似乎也很重要，因为钠负荷加速了高血压的发展。从这些研究中可以看出，在半肾切除的受试者中，高血压很容易发展，这可能是由于排泄功能有限，其中剩余肾脏的代偿功能可能起着重要作用。