Roles of Vartous Natriuretic Factors in Essential Hypertensives

多种利尿钠因子在原发性高血压中的作用

• 批准号: 63480195
• 负责人: SARUTA Takao
• 金额: $ 2.56万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480195/
• 关键词: Essential hypertensives; Natriuesis; Renin-angiotensin system; Dopamine; Na, K-ATPase inhibitors; Kallikrein-kinin system; Na利尿; Na利尿ホルモン; 心房性Na利尿ペプチド; 食塩負荷

The roles of various natriuretic factors in the pathogenesis of hypertension was studied in genetically hypertensive rats such as spontaneously hypertensive rats (SHR) and Dahl salt sensitive (D-S) or salt resistant (D-R) rats and in essential hypertensives, In the experiments using an in vivo renal perfusion system, it was considered that natriuresis was mainly dependent on activity of the renin-angiotensin (R-A) system in SHR, since disturbed natriuretic response to salt infusion was improved by the administration of an angiotensin converting enzyme (ACE) inhibitor, MK422 (enalaprilat). In D-s rats natriuetic response was not improved by MK422. As natriuretic response in D-R rats aggravated by the administration of indomethacin to the extent similar to that D-S tats, it was supposed that disturbed production of prostaglandins such as PGE_2 and PGF_2 may play an important role in D-S rats.In essential hyportensives natriuretic response to acute salt loading seemed to be controlled by … More the sympathetic nerve activity, activity of the R-A system and various natriuretic factors such as dopamine, kallikrein system, prostaglandins, atrial natriuretic poptide (ANP) and Na,K-ATPase inhibitors. In patients with nomal or high renin the sympathetic nerve activity and the R-A system seemed to play an important role in the control of natriuresis. In some patients with low renin who showed disturbed natriuresis, dopamine and the kallikrein-kinin system in the kidney seemed to be important for the ANP between patients with normal natriuesis and those with disturbed natriuesis. In some patients with low renin essential hyportensives, urinary excretion of Na, K-ATPase inhibitors was increased.From these studies it was concluded that urinary excretion of sodium is disturbed in essential hypertensives and in genetically hypertensives rats and its disturbance may be related to the development of hypertension. The causes of the disturbance in urinary excretion of sodium are various in each patient and rat species. Less

在自发性高血压大鼠(SHR)、Dahl盐敏感(D-S)或耐盐(D-R)大鼠等遗传性高血压大鼠和高血压患者中，研究了各种利钠因子在高血压发病机制中的作用。在体内肾灌流系统的实验中，认为SHR的利钠主要依赖于肾素-血管紧张素(R-A)系统的活性，因为给予血管紧张素转换酶(ACE)抑制剂MK422(依那普利拉)可改善盐灌流引起的紊乱的利钠反应。MK422对D-S大鼠的利钠反应无明显改善作用。由于给予消炎痛加重D-R大鼠的利钠反应，其程度与D-S类似，推测前列腺素E_2和前列腺素F_2的分泌紊乱可能在D-S大鼠中起重要作用。在原发性高血压大鼠中，对急性盐负荷的利钠反应似乎由…控制更多的是交感神经活动、R-A系统的活动以及各种利钠因子，如多巴胺、激肽释放酶系统、前列腺素、心钠素(ANP)和Na，K-ATPase抑制剂。在肾素正常或升高的患者中，交感神经活动和R-A系统似乎在控制钠尿方面起着重要作用。在某些尿钠紊乱的低肾素患者中，肾脏中的多巴胺和激肽释放酶-激动素系统似乎对钠尿正常和钠尿紊乱患者之间的ANP有重要作用。部分肾素低血压者尿钠、钾-三磷酸腺苷酶抑制剂排泄增加，提示高血压病患者和遗传性高血压大鼠尿钠排泄紊乱，其紊乱可能与高血压的发生发展有关。尿钠排泄障碍的原因在不同的患者和大鼠种类中是不同的。较少

项目成果

Takenaka T: "The role of the kidney on the development and maintenance of hypertension." J Keio Med Soc. 66. 1267-1281 (1989)

Takenaka T：“肾脏在高血压发生和维持中的作用。”

Saruta T: "Role of various natriuretic substances in essential hypertension." Byotai Seiri. 9. 826-829 (1990)

Saruta T：“各种利尿钠物质在原发性高血压中的作用。”

Kawabe H,Furukawa T,Takenaka T,Saruta T: "Importance of reninーangiotensin system in sodium regulation in essential hypertension" Am J Hypertens. 4. 119-125 (1991)

Kawabe H、Furukawa T、Takenaka T、Saruta T：“肾素-血管紧张素系统在原发性高血压钠调节中的重要性”Am J Hypertens。 4. 119-125 (1991)

Furukawa T: "Renal and endocrine responses to saline infusion in essential hypertension" J Keio Med Soc. 66. 357-369 (1989)

Furukawa T：“原发性高血压患者对盐水输注的肾脏和内分泌反应”J Keio Med Soc。

猿田 享男: "本態性高血圧における諸種Na利尿因子の役割" 病態生理. 9. 826-829 (1990)

Yasuo Saruta：“各种利尿钠因素在原发性高血压中的作用”病理生理学 9. 826-829 (1990)。