Roles of Vartous Natriuretic Factors in Essential Hypertensives

多种利尿钠因子在原发性高血压中的作用

• 批准号: 63480195
• 负责人: SARUTA Takao
• 金额: $ 2.56万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480195/
• 关键词: Essential hypertensives; Natriuesis; Renin-angiotensin system; Dopamine; Na, K-ATPase inhibitors; Kallikrein-kinin system; Na利尿; Na利尿ホルモン; 心房性Na利尿ペプチド; 食塩負荷

The roles of various natriuretic factors in the pathogenesis of hypertension was studied in genetically hypertensive rats such as spontaneously hypertensive rats (SHR) and Dahl salt sensitive (D-S) or salt resistant (D-R) rats and in essential hypertensives, In the experiments using an in vivo renal perfusion system, it was considered that natriuresis was mainly dependent on activity of the renin-angiotensin (R-A) system in SHR, since disturbed natriuretic response to salt infusion was improved by the administration of an angiotensin converting enzyme (ACE) inhibitor, MK422 (enalaprilat). In D-s rats natriuetic response was not improved by MK422. As natriuretic response in D-R rats aggravated by the administration of indomethacin to the extent similar to that D-S tats, it was supposed that disturbed production of prostaglandins such as PGE_2 and PGF_2 may play an important role in D-S rats.In essential hyportensives natriuretic response to acute salt loading seemed to be controlled by … More the sympathetic nerve activity, activity of the R-A system and various natriuretic factors such as dopamine, kallikrein system, prostaglandins, atrial natriuretic poptide (ANP) and Na,K-ATPase inhibitors. In patients with nomal or high renin the sympathetic nerve activity and the R-A system seemed to play an important role in the control of natriuresis. In some patients with low renin who showed disturbed natriuresis, dopamine and the kallikrein-kinin system in the kidney seemed to be important for the ANP between patients with normal natriuesis and those with disturbed natriuesis. In some patients with low renin essential hyportensives, urinary excretion of Na, K-ATPase inhibitors was increased.From these studies it was concluded that urinary excretion of sodium is disturbed in essential hypertensives and in genetically hypertensives rats and its disturbance may be related to the development of hypertension. The causes of the disturbance in urinary excretion of sodium are various in each patient and rat species. Less

在遗传性高血压大鼠（例如赞助的高血压大鼠（SHR）和DAHL盐敏感（D-S）和耐盐性（D-R）大鼠和基本高血压剂中，在遗传性高血压大鼠中，在遗传性高血压大鼠中研究了各种亚硝酸盐因子在高血压的发病机理中的作用，并研究了肾脏对肾脏的兴奋性系统的依赖性，而不是肾脏的兴奋性系统。 （R-A）SHR的（R-A）系统，由于施用血管紧张素转化酶（ACE）抑制剂MK422（Enalaprilat），因此改善了脂肪尿液对盐输注的反应。在D-S大鼠中，MK422并未改善纳位反应。由于通过给予吲哚美辛与D-S TAT相似的D-R大鼠的负D-R大鼠的脂肪酸反应，因此被认为影响了PGE_2和PGF_2等前列腺素的产生，可能在D-S Rat中起重要作用。亚钠尿素因子，例如多巴胺，kallikrein系统，前列腺素，心房脂肪蛋白poptide（ANP）和Na，K-ATPase抑制剂。在名义或高肾素的患者中，交感神经活动和R-A系统似乎在控制纳特里雷SIS中起着重要作用。在某些肾脏炎症患者中，肾脏中的肾上腺素，多巴胺和肾脏中的kallikrein-Kinin系统的患者对于正常Natriuesis患者与患有Natriuesis的患者之间的ANP似乎很重要。在某些肾素低敏敏性高敏剂的患者中，NA的极端尿，K-ATPase抑制剂增加了。从这些研究得出的结论是，钠的极端钠在基本高血压和遗传性高血压大鼠中是异常的，其障碍可能与高血压的发展有关。每个患者和大鼠物种的尿中极端灾难的原因是各种各样的。较少的

项目成果

Takenaka T: "The role of the kidney on the development and maintenance of hypertension." J Keio Med Soc. 66. 1267-1281 (1989)

Takenaka T：“肾脏在高血压发生和维持中的作用。”

Saruta T: "Role of various natriuretic substances in essential hypertension." Byotai Seiri. 9. 826-829 (1990)

Saruta T：“各种利尿钠物质在原发性高血压中的作用。”

Furukawa T: "Renal and endocrine responses to saline infusion in essential hypertension" J Keio Med Soc. 66. 357-369 (1989)

Furukawa T：“原发性高血压患者对盐水输注的肾脏和内分泌反应”J Keio Med Soc。

猿田 享男: "本態性高血圧における諸種Na利尿因子の役割" 病態生理. 9. 826-829 (1990)

Yasuo Saruta：“各种利尿钠因素在原发性高血压中的作用”病理生理学 9. 826-829 (1990)。

Kawabe H,Furukawa T,Takenaka T,Saruta T: "Importance of reninーangiotensin system in sodium regulation in essential hypertension" Am J Hypertens. 4. 119-125 (1991)

Kawabe H、Furukawa T、Takenaka T、Saruta T：“肾素-血管紧张素系统在原发性高血压钠调节中的重要性”Am J Hypertens。 4. 119-125 (1991)