Role of central GABA system in hypertension induced by high salt and stress.

中枢GABA系统在高盐和应激诱发的高血压中的作用。

• 批准号: 03454256
• 负责人: TAKESHITA Akira
• 金额: $ 3.97万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454256/
• 关键词: borderline hypertensive rat; NaCl; muscimol; shaker stress; sympathetic nerve activity; GABA; muscimol; 食塩; 境界型高血圧; ストレス; ムシモ-ル; ビククリン; 脳室内投与

We aimed to determine 1) if high salt diet augments the pressor response to shaker stress in borderline hypertensive rats (BHR) and 2) if ICV muscimol attenuates the augmented pressor response to shaker stress in high-salt BHR. The studies were done in conscious BHR and WKY of the two groups (high and normal salt diet for 5 weeks). The results demonstrated the following findings : 1) high salt intake increased resting arterial pressure and augmented pressor response to shaker stress in BHR but not in WKY, 2) ICV muscimol caused a greater decrease in mean arterial pressure and renal sympathetic nerve activity in BHR-NaCl than in BHR-control, 3) ICV muscimol attenuated the pressor response to shaker stress dose-dependently in BHR-NaCl but did not alter it in BHR-control or in WKY, and 4) Resting mean arterial pressure and the pressor response to shaker stress in BHR-NaCl after ICV muscimol did not differ form those in BHR-control. These results suggest that high salt intake may reduce the sympathetic inhibitory effect of central GABA system, which may contribute to salt-induced hypertension and the augmented response to stress in BHR.

我们的目的是确定1）高盐饮食是否增强临界高血压大鼠（BHR）对振动应激的升压反应，2）ICV蝇蕈醇是否减弱高盐BHR对振动应激的升压反应。实验在清醒的BHR和WKY两组中进行（高盐和正常盐饮食5周）。结果显示了以下发现：1）高盐摄入增加了BHR的静息动脉压和对振动应力的升压反应，但WKY没有，2）ICV蝇蕈醇引起BHR-NaCl组的平均动脉压和肾交感神经活性比BHR-对照组更大的降低，3）ICV蝇蕈醇剂量依赖性地减弱BHR-NaCl对振动应激的升压反应，但对BHR-对照组和WKY无明显影响;（4）侧脑室注射蝇蕈醇后，BHR-NaCl组的静息平均动脉压和对振动应力的升压反应与BHR对照组无明显差异。这些结果提示，高盐摄入可降低中枢GABA系统的交感神经抑制作用，这可能与盐诱导的高血压和BHR对应激反应的增强有关。

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