Analysis of virulent mechanism of periodontal pathogen that invades in the mucosal epithelium cells and of effect of antibiotics on the invaded bacterium.

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Although it has been demonstrated that the periodontal disease pathogen Porphyromonas gingivalis is able to invade into various types of cell in the periodontal tissue including oral mucosal epithelial cells, there are few studies that examine whether the bacterial invasion contribute to the pathogenic mechanisms involved in the lead of the exacerbation of the disease. Then, we have investigated the effect of the bacterial invasion on the human mucosal epithelial cell line KB cells in this study. Therefore, this study showed that the bacterial invasion is able to induce the expression of IL-6 in the cells.