A STUDY OF INTRATUMORAL DISTRIBUTION OF Gd-DTPA ON DYNAMIC MRI

动态MRI上Gd-DTPA瘤内分布的研究

• 批准号: 03454283
• 负责人: KONO Michio
• 金额: $ 2.37万
• 依托单位: KOBE UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454283/
• 关键词: dynamic MRI; Gd-DTPA; tumor; lung cancer; hepatocellular carcinoma; rabbit VX2 tumor; 腫瘍内動態; 家兎VX-2腫瘍; 血管透過性; 家兎VXー2腫瘍; GdーDTPA; 腫瘍伝動態; 組織内濃度; 組織内移行; 悪性腫瘍

1)The purpose was to clarify the intratumoral distibution of Gd-DTPA on dynamic MRI.2)Experimental study : a)In a study using rabbit VX2 tumor, alteration of Gd-DTPA concentration in the tumor revealed significantly different from that around tumor and from that of normal tissue. The result meant that dynamic MRI reflected the difference of vascular permeability of various tissues including tumor and that dynamic MRI contributed to the diagnosis of tissue characteristics.In a study using resected human lung specimen containing cancer, alteration of Gd-DTPA concentration in the tumor revealed pararell to that of signal intensity of the tumor on MRI taken preoperatively, and also revealed low concentration of Gd-DTPA in the necrotic tissue.3)Clinical Study : In a time-intensity curve analysis of lung cancer on the T1 weighted dynamic study, signal intensity of the lung cancer showed a rapid increase and reached the peak at the time of 3-10 minutes and showed gradual decrease to the time of 30 minutes after injection of contrast medium. Gd-DTPA enhanced MRI was useful in the diagnosis of tumor extent of lung cancer with secondary change, differential diagnosis of tuberculoma, therapeutic effect after conservative therapy, diagnosis of recurrence from radiation pneumonitis. As for diagnosis for hepatocellular carcinoma, over all accuracy of dynamic MRI revealed superior to that of conventional T2 weighted images especially in the diagnosis of therapeutic effect and recurrence.4)Conclusion : We studied the distribution of Gd-DTPA in and around the tumor on dynamic MRI experimentally and clinically. Dynamic MRI was a very useful modality to diagnose tumor viability. However, tumor stain by Gd-DTPA mainly depends on the vascular permeability. Research of tumor specific contrast media is essential.

1)2）实验研究：（1）兔VX 2肿瘤内Gd-DTPA浓度变化与瘤周及正常组织有显著性差异。结果表明，动态MRI反映了包括肿瘤在内的各种组织血管通透性的差异，有助于对组织特性的诊断，在一项含癌人肺切除标本的研究中，肿瘤中Gd-DTPA浓度的变化与术前MRI肿瘤信号强度的变化相似，并显示坏死组织中Gd-DTPA浓度较低。3）临床研究：在肺癌T1加权动态研究的时间-强度曲线分析中，肺癌的信号强度在注射造影剂后3-10分钟迅速增加并达到峰值，并在注射造影剂后30分钟逐渐降低。Gd-DTPA增强MRI对肺癌继发改变的肿瘤范围的诊断、结核球的鉴别诊断、保守治疗后的疗效、放射性肺炎复发的诊断有重要价值。对肝癌的诊断，动态MRI总体上上级常规T2加权像，尤其是对疗效和复发的诊断。4）结论：我们通过实验和临床研究了动态MRI对肿瘤内及周围Gd-DTPA的分布。动态MRI是诊断肿瘤活性的一种非常有用的方法。而Gd-DTPA对肿瘤的染色主要依赖于血管的通透性。肿瘤特异性造影剂的研究是必要的。

项目成果

Kusumoto M,Sakai E,Yamasaki K,Fujii M,Itouji E,Endo M,Meno S,Adachi S,Kono M,shimizu T: Japanese Jounal of Diagnostic Imaging. 12. 36-44 (1992)

Kusumoto M，Sakai E，Yamasaki K，Fujii M，Itouji E，Endo M，Meno S，Adachi S，Kono M，shimizu T：日本诊断影像杂志。

Kono M,Adachi S.Kusumoto M,Sakai E: "Clinical utility of Gd-DTPA-enhanced magnetic resonance imaging in lung cancer." Journal of thoracic Imaging. 8(1). 18-26 (1993)

Kono M、Adachi S.Kusumoto M、Sakai E：“Gd-DTPA 增强磁共振成像在肺癌中的临床应用。”

河野 通雄,足立 秀治,楠本 昌彦,酒井 英郎,糸氏 英一郎,山崎 克人,目野 茂宣,遠藤 正浩: "〔臨時増刊号 胸部のCT・MRI〕肺癌ー縦隔・胸壁・横隔膜への転移進展を含むー" 臨床放射線. 36(11). 1483-1495 (1991)

Michio Kono、Hideharu Adachi、Masahiko Kusumoto、Hideo Sakai、Eiichiro Itoji、Katsuto Yamazaki、Shigenobu Meno、Masahiro Endo：“[特刊胸部 CT/MRI] 肺癌 - 转移至纵隔、胸壁和膈肌”临床放射学36（11）。

楠本 昌彦,酒井 英郎,山崎 克人,藤井 正彦,糸氏 英一郎,遠藤 正浩,目野 茂宣,足立 秀治,河野 通雄,清水 雅史: "肺癌におけるDynamic MRIの有用性" 画像診断. 12(1). 36-44 (1992)

Masahiko Kusumoto、Hideo Sakai、Katsuto Yamazaki、Masahiko Fujii、Eiichiro Itoji、Masahiro Endo、Shigenobu Meno、Hideharu Adachi、Michio Kono、Masashi Shimizu：“动态 MRI 在肺癌中的作用”12(1) .36-44。 (1992)

KusumotoM,Kono M.Adachi S,Yamasaki K,Itouji E,Sakai E, Endo M, Nakamura T,Kimura K: "Gd-DTPA enhanced MR imaging for lung nodules : Differentiation of lung cancer and tuberculoma." Investigative Radiology. (in print). (1994)

KusumotoM、Kono M.Adachi S、Yamasaki K、Itouji E、Sakai E、Endo M、Nakamura T、Kimura K：“Gd-DTPA 增强肺结节 MR 成像：肺癌和结核瘤的鉴别。”