MEASUREMENT OF T1-T2 RELAXIVITIES OF LIPOSOMAL GD-DTPA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项工作的目的是确定不同浓度钆造影剂包封的Gd-DTPA脂质体的T1和T2弛豫度。这些研究将确定在使用t1加权技术进行MR成像时可在体内使用的最佳配方。这将导致获得更高的信噪比（SNR）和对比噪声比（CNR）的图像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this work are to determine T1 and T2 relaxivities of Liposomal Gd-DTPA encapsulating different concentration of gadolinium contrast agents. The studies will identify the optimal formulation that can be used in vivo when performing MR imaging using T1-weighted techniques. This will result in obtaining images with higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).