MEASUREMENT OF T1-T2 RELAXIVITIES OF LIPOSOMAL GD-DTPA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本工作的目的是测定脂质体Gd-DTPA包封不同浓度钆对比剂的T1和T2弛豫率。这些研究将确定使用T1加权技术进行MR成像时可在体内使用的最佳制剂。这将导致获得具有更高信噪比（SNR）和对比度噪声比（CNR）的图像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this work are to determine T1 and T2 relaxivities of Liposomal Gd-DTPA encapsulating different concentration of gadolinium contrast agents. The studies will identify the optimal formulation that can be used in vivo when performing MR imaging using T1-weighted techniques. This will result in obtaining images with higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).