MEASUREMENT OF T1-T2 RELAXIVITIES OF LIPOSOMAL GD-DTPA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this work are to determine T1 and T2 relaxivities of Liposomal Gd-DTPA encapsulating different concentration of gadolinium contrast agents. The studies will identify the optimal formulation that can be used in vivo when performing MR imaging using T1-weighted techniques. This will result in obtaining images with higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).