Morphological and Physiological Studies for Age-Related Change in Gerbil's Cochlear Nucleus
沙鼠耳蜗核随年龄变化的形态学和生理学研究
基本信息
- 批准号:03454410
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A degenerative lesion of the auditory system of mongolian gerbil (Meriones unguiculatus) was reported by K.Morest et al., 1986. The lesion was evaculation confined to the cochlear nucleus (CN) and increased with age. This study was performed to explore an effect of age-related lesion in gerbil's CN on the auditory function. 30 gerbils from 21 days to 2 years and 3 months old were used. They have had no ear infection. The auditory function was electrophysiologically evaluated by recording of cochlear microphonics (CM) and auditory brain stem response (ABR). Then CN and cochlea were microscopically observed. Correlation of the occurrence of lesion was examined with change of CM and ABr.Evaculation in gerbil's CN began to appear at around 7 weeks of age and the lesion increased in number and size with age. Number of vacuoles in average was less than 5 for 7-week-old gerbils and more than 15 for over 4-month-old gerbils. Mean size of each vacuole was smaller than 50 mum^2 for the former ge … More rbils and became larger than 150 mum^2 for the latter. Unlikely with the age-related changes in the cochlear nucleus, no vacuole was seen in cochlea. CM thresholds of gerbils at the frequency range of 1 k - 8kHz increased with aging. The CM thresholds of 4-month-old gerbil were 20-30 dB lower than those of the over 2-year-old gerbils. Similarly with the change of CM thresholds, ABR thresholds increased 15-20 dB with their age. Latencies of ABR waves became elongated along with the increased thresholds. Inter-wave latencies between I and V were also more prolonged in over 2-year-old gerbils than in the younger gerbils. However this delay was almost same with the prolongation of latencies which was caused by the increased thresholds of ABR.The results of CM and ABR in this study showed that auditory function in the cochlea and brain stem pathway of gerbils reached adult levels at about 4 months of age and gradually decreased with age. So far we have not found the direct effect of lesions in the CN on the age-related auditory function of gerbils. Less
K.Morest等人于1986年报道了蒙古沙鼠(Meriones unguiculatus)听觉系统的退行性病变。病变局限于耳蜗核(CN),并随着年龄的增长而加重。本研究旨在探讨沙鼠中枢神经系统年龄相关损伤对听觉功能的影响。使用30只21天龄至2岁3个月龄的沙鼠。他们没有耳部感染。通过记录耳蜗微音(CM)和听觉脑干反应(ABR)来对听觉功能进行电生理学评估。然后对CN和耳蜗进行显微镜观察。考察病变发生与CM、ABr变化的相关性。沙鼠CN在7周龄左右开始出现排空现象,且随着年龄的增长,病变的数量和大小逐渐增多。 7周龄沙鼠平均液泡数少于5个,4月龄以上沙鼠平均液泡数超过15个。对于前者,每个液泡的平均大小小于 50 mum^2,对于后者,每个液泡的平均大小大于 150 mum^2。与耳蜗核中与年龄相关的变化不太可能的是,耳蜗中没有看到液泡。沙鼠在 1 k - 8kHz 频率范围内的 CM 阈值随着年龄的增长而增加。 4月龄沙鼠的CM阈值比2岁以上沙鼠低20-30dB。与 CM 阈值的变化类似,ABR 阈值随着年龄的增长而增加 15-20 dB。 ABR 波的潜伏期随着阈值的增加而变长。两岁以上沙鼠的 I 波和 V 波间潜伏期也比年轻沙鼠更长。然而这种延迟与ABR阈值升高引起的潜伏期延长几乎相同。本研究的CM和ABR结果表明,沙鼠耳蜗和脑干通路的听觉功能在4月龄左右达到成年水平,并随着年龄的增长而逐渐下降。迄今为止,我们尚未发现中枢神经系统病变对沙鼠年龄相关听觉功能的直接影响。较少的
项目成果
期刊论文数量(28)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
枝松,秀雄: "聴覚中枢路の経時的変性の種特異性の形態学的検討" 日本耳鼻咽喉科学会会報. 96(10). 1647 (1993)
Edamatsu, Hideo:“中枢听觉通路时间变性的形态学研究”日本耳鼻喉科协会通报 96(10)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
H.Edamatsu: "Gerbil's Age-related Auditory Function & Degeneration of Cochlear Nucleus." XXI International Congress of Audiology.45. 44- (1992)
H.Edamatsu:“沙鼠的与年龄相关的听觉功能
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
枝松秀雄: "聴覚中枢路の経時的変性の種特異性の形態学的検討" 日本耳鼻咽喉科学会会報. 96(10). 1647 (1993)
Hideo Edamatsu:“中枢听觉通路时间变性的形态学研究”日本耳鼻喉科协会通报 96(10)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
枝松 秀雄: "スナネズミの蝸牛神経核変性の聴覚系に及ぼす影響" Audiology Japan. 34(5). 511-512 (1991)
Hideo Edamatsu:“沙鼠耳蜗核变性对听觉系统的影响”日本听力学 34(5) 511-512 (1991)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Edamatsu Hideo: "Effect of lesion in gerbil's cochlear nucleus on auditory function." Audiology Japan.34(5). 511-512 (1991)
Edamatsu Hideo:“沙鼠耳蜗核损伤对听觉功能的影响。”
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- 影响因子:0
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