Amphiphilic nanogels based on aliphatic polycarbonates: New biodegradable nanocarriers for hydrophobic compounds

该项目将开发一种新的多功能合成平台，以方便和可扩展地制备两亲性纳米凝胶。基于两亲性脂肪族聚碳酸酯网络，这些新型的可生物降解胶体材料将使疏水化合物的负载和释放变得可调。虽然传统的整体亲水纳米凝胶输送系统仅限于亲水货物，但这一概念将为输送疏水药物开辟新的治疗选择。我们的方法将能够精确地调整纳米凝胶的两亲性，以适应不同的疏水货物，而不会影响纳米凝胶载体的胶体特征(尺寸、形状、交联性)。因此，未来将开发的载体系统将使不同纳米凝胶-药物组合的治疗效率具有理想的可比性。该项目结合了多种概念和方法，开展了涵盖化学、毒理学和制药方面的跨学科合作。

This project will develop a new versatile synthetic platform for the facile and scalable preparation of amphiphilic nanogels. Based on amphiphilic aliphatic polycarbonate networks, these new biodegradable colloidal materials will enable the tunable loading and release of hydrophobic compounds. While conventional overall hydrophilic nanogel delivery systems are limited to hydrophilic cargoes, this concept will open up new therapeutic options for the delivery of hydrophobic drugs. Our approach will enable precise adjustment of nanogel amphiphilicity to different hydrophobic cargoes without affecting the colloidal features (size, shape, crosslinking) of the nanogel carrier. As a result, the carrier system to be developed will, in future, enable an ideal comparability between therapeutic efficiencies of different nanogel-drug combinations. This project combines multiple concepts and methods in an interdisciplinary cooperation covering chemical, toxicological and pharmaceutical aspects.