Design, development and testing of novel inflammation resolving stimuli-responsive nanogels

新型炎症消解刺激响应纳米凝胶的设计、开发和测试

• 批准号: 2601038
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2601038
• 关键词: Design; development; testing; novel; inflammation

Nanogels are hydrogels within the nanometer range consisting of cross-linked porous polymer networks with the ability to retain high volumes of water or biological fluids while maintaining their structure. They have a wide range of flexibility in their design, allowing their characteristics such as size, charge, degree of porosity, and degradability to be easily tuned by the choice of monomeric building blocks. Because nanogels can retain a high volume of water, they are extremely biocompatible. This excellent and unique property makes them an ideal nanoplatform for the delivery of biological drugs, such as enzymes and proteins. To this end, this project will focus on the development of stimuli-responsive nanogels that can deliver highly potent innate biological payloads such inflammation resolving proteins, peptides and also nucleic acids

纳米凝胶是由交联的多孔聚合物网络组成的纳米范围内的水凝胶，具有保留高体积的水或生物流体同时保持其结构的能力。它们在设计上具有广泛的灵活性，允许它们的特性，如尺寸，电荷，孔隙度和降解性，可以通过选择单体构建块来轻松调整。因为纳米凝胶可以保留大量的水，所以它们是非常生物相容的。这种优异和独特的性质使其成为递送生物药物（如酶和蛋白质）的理想纳米平台。为此，该项目将专注于开发刺激响应纳米凝胶，该纳米凝胶可以提供高度有效的先天生物有效载荷，如炎症解决蛋白质，肽和核酸