Design, development and testing of novel inflammation resolving stimuli-responsive nanogels

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Nanogels are hydrogels within the nanometer range consisting of cross-linked porous polymer networks with the ability to retain high volumes of water or biological fluids while maintaining their structure. They have a wide range of flexibility in their design, allowing their characteristics such as size, charge, degree of porosity, and degradability to be easily tuned by the choice of monomeric building blocks. Because nanogels can retain a high volume of water, they are extremely biocompatible. This excellent and unique property makes them an ideal nanoplatform for the delivery of biological drugs, such as enzymes and proteins. To this end, this project will focus on the development of stimuli-responsive nanogels that can deliver highly potent innate biological payloads such inflammation resolving proteins, peptides and also nucleic acids