Neurochemical and neurophysiological mechanisms in the interaction of reward processing with bottom-up and top-down networks: The role of dopamine and E/I balance (B07)

奖励处理与自下而上和自上而下网络相互作用的神经化学和神经生理学机制：多巴胺和 E/I 平衡的作用 (B07)

• 批准号: 431445446
• 金额: --
• 依托单位: Zentrum für Psychiatrie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/431445446?language=en
• 关键词: Neurochemical; neurophysiological; mechanisms; interaction; reward

Project B07 investigates the interaction of bottom-up and top-down visual attention with reward processes in healthy subjects and patients with schizophrenia. The main focus of project B07 lies on the neurophysiological and neurochemical mechanisms of this interaction. We will use neuropharmacological modulation at the dopamine receptor together with trial-by-trial coupling of simultaneous EEG-fMRI, multichannel-tACS and advanced electrical field modeling to probe the causal role of neural oscillations in this process and MR-Spectroscopy to characterize the relationship of glutamate concentrations in the visual cortex and the ACC with visual selection.

项目B 07研究了健康受试者和精神分裂症患者自下而上和自上而下的视觉注意与奖励过程的相互作用。项目B 07的主要重点在于这种相互作用的神经生理学和神经化学机制。我们将使用多巴胺受体的神经药理学调制，同时进行EEG-fMRI，多通道tACS和高级电场建模的试验耦合，以探索神经振荡在此过程中的因果作用，并利用MR光谱来表征视觉皮层和ACC中谷氨酸浓度与视觉选择的关系。