New gallstone solvent with dissolving action for mucin in the gallstone.

我们对胆囊结石的成分进行了分析，结果表明：（1）胆结石中存在核蛋白网络结构，它对胆结石起到了建设性作用，（2）胆结石中的核蛋白是硫酸化糖蛋白作为酸性核蛋白。在这个结果中，我们尝试以乙酰半胱氨酸为核溶剂溶解胆囊结石核，乙酰半胱氨酸在体外对胆囊结石有较好的溶解作用，乙酰半胱氨酸为酸性物质，乙酰半胱氨酸在pH 7.5 ~ 8.0范围内崩解效果最好。我们检查了注射到输精管中的乙酰基斯坦的毒性。组织化学和血液生化检查未见急性和慢性毒性反应，提示乙酰半胱氨酸是一种溶石剂，其溶石机理是溶解胆囊结石中的核蛋白网络。

We performed the analysis of the composition of gallstones, and obtained the results that ; (1)there were the nucine-network structures into the gallstones, which carried out the Constructive role of the gallstone, (2)nucin into the gallstones were the sulfated glyeoprotein as a acidic nucin.In this result, we tried to dissolve the gallstone nucin by ascetylcystein as a nucous solvent.Acetylcystein disintegrated theall Rind of gallstones in vitro prompthy.Acelytystein was acidic substunce and neutrized by NaltCO_3 in use.Disintegrating action of acetylcystein was best under the Condition of pH 7.5-8.0. We examined the toxicity of acetylystein injecting into the bete duct. Gcute and chronic toxicity was not observed in histochemicaly and blood demically.Conculusion, we think the acetylcystein is a gallstone solvent, by mechanism of the dissolved nucin network in the gallstone.