美拉德反应形成的老化蛋白交联剂的质谱分析-猫眼课题宝

美拉德反应形成的老化蛋白交联剂的质谱分析

批准号：

04836009

负责人：

NIWA Toshimitsu

金额：

$1.22万

依托单位：

Nagoya University

依托单位国家：

日本

项目类别：

Grant-in-Aid for General Scientific Research (C)

财政年份：

1992

资助国家：

日本

项目状态：

已结题

起止时间：

1992 至 1993

来源：

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04836009/

关键词：

Maillard reaction 3-deoxyglucosone gas chromatography mass spectrometry diabetes mellitus diabetic nephropathy タンパク質架橋重合グルコース質量分析法電気泳動 HPLC

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英文摘要

3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic comlications such as diabetic nephropathy by promoting the formation of advanced glycation end products.

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会议论文

Toshimitsu NIWA: "Presence of 3-deoxyglucosone,a potent protein crosslinking intermediate of Maillard Reaction,in diabetic serum." Biochem Biophys Res Commun. 196. 837-843 (1993)

Toshimitsu NIWA：“糖尿病血清中存在 3-脱氧葡萄糖醛酮，一种美拉德反应的有效蛋白质交联中间体。”

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