Advancement of the Functions of Molecular Assemblies Composed of Amphiphilic Molesules

两亲性分子组成的分子组装体功能的研究进展

基本信息

批准号：
05453095
负责人：
HARADA Makoto
金额：
$ 4.29万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

We performed the studies on advancing the functions of a microemulsion which is a kind of molecular assemblies composed of amphiphilic molecules. The obtained results are as follows.1. Functions of unit molecular assembly : We elucidated the fundamental items for advancing the functions of unit assembly ; (1) theoretical model relating the surfactant molecular form with the geometry of the assembly, (2) the behaviors of the surfactant systems yielding spherical and cylindrical assemblies, (3) the characteristics of the solubilization of guest molecules into the host assemblies, (4) the characteristics of the assemblies in non-ionic surfactant systems and in non-ionic and anionic mixed surfactant systems, and (5) the roles of the assemblies in the preparation of CdS fine particles.2. Functions of surfactant/protein systems : We elucidated the driving force for solubilizing proteins in the assemblies and the solubilization dynamics of guest molecules. Based on these, we proposed the methods of tailoring molecular assemblies for protein solubilization and selective separation of proteins without denaturation of proteins. The methods are based on regulating the electrostatic and affinity interactions between proteins and surfactants.3. Functions of concentrated assembly systems : We elucidated the static and dynamic characteristics both of the spherical assembly system composed of concentrated Aerosol-OT and of the network micro-structures in concentrated sodium bis (2ethylhexyl) phosphate system. We also obtained fundamental information on the solidification of nano-structures in microemulsions.

我们进行了有关推进微乳液功能的研究，这是一种由两亲分子组成的分子组件。获得的结果如下1。单位分子组装的功能：我们阐明了基本项目以推进单位组装的功能；（1）理论模型将表面活性剂分子形式与装配的几何形状相关联，（2）表面活性剂系统的行为产生球形和圆柱体组件，（3），（3）客人分子在宿主组装中溶解的特征，（4）（（4）（（4）非征服者的特征，（4）非征服者的特征 - （4）非效果的特征系统，以及（5）组件在CD -FINE颗粒制备中的作用2。表面活性剂/蛋白质系统的功能：我们阐明了在组件中溶解蛋白质和来宾分子的溶解动力学的驱动力。基于这些，我们提出了定制分子组件的方法，以蛋白质溶解和蛋白质的选择性分离而无需蛋白质变性。该方法基于调节蛋白质与表面活性剂之间的静电和亲和力相互作用3。浓缩组装系统的功能：我们阐明了由浓缩的气溶胶-OT和浓浓度钠钠（2乙基己基）磷酸磷酸钠磷酸钠组成的球形组装系统和网络微结构组成的静态和动态特性。我们还获得了有关微乳液中纳米结构固化的基本信息。