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Development of magnetically suspended centrifugal pump (MSCP) and operation system

磁悬浮离心泵（MSCP）及操作系统的开发

基本信息

批准号：
05454384
负责人：
BAN Toshihiko
金额：
$ 4.1万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454384/
关键词：
Magnetically suspended centrifugal pump Assist heart Left ventricular assist Hemolysis test Thrombus Long-term animal experiment Coating 溶血抗血栓性エネルギー効率温度上昇

项目摘要

To overcome problems derived from the shaft within conventional centrifugal pump, we have developed a magnetically suspended centrifugal pump (MSCP) , which operates as a bearingless sealless centrifugal pump. The impeller is suspended freely and centrally by magnetic force within the pump. Hemolysis tests were performed in comparison with the Biopump. Index of hemolysis and destruction of platelets were significantly lower in the MSCP.Animal studies were designed to evaluate antithrombogenecity and durability of the MSCP.Short-term animal studies in which several coating methods on the impeller of the pump were investigated showed that silicon coating was best with results of no thrombus on the surface after continuous pumping for 24 hours. Long-term animal studies were performed using 5 sheep weighing 40 - 50 kg. The left heart by pass was established with a withdrawal cannula into the left atrium and a return cannula into the descending aorta. Heparin was given for anticoagulation only at cannulation, and Warfarin was orally administrated subsequently to keep the prothrombin time 1.5 to 2.0 folds. Five sheep survived more than two weeks with 46 days of the longest survival. The pump flow rate obtained during the pumping was 3.0 to 5.0 l/min. The free hemoglobin concentration was less than 20 mg/dl, and other parameters relating biochemistry were within normal ranges. The cause of termination was thrombus formation in the cannula in two, systemic infection in one, gastrointestinal disturbance in one, and thrombus inside the pump in one sheep, that was the longest survival. These results suggest that the MSCP could be durable for at least more than a month, and is promising for application of long-term circulatory assist device, whch is mandatory to rescue patients with the profound heart failure.

为了克服传统离心泵中轴的问题，我们开发了一种磁悬浮离心泵（MSCP），其作为无轴承无密封离心泵运行。叶轮通过磁力自由地悬挂在泵内的中心。与Biopump相比，进行了溶血试验。动物实验结果表明，MSCP具有良好的抗血栓性和耐久性，对泵叶轮表面几种涂层方法的短期动物实验结果表明，硅涂层效果最好，连续泵送24 h后，叶轮表面无血栓形成。使用5只体重40 - 50 kg的绵羊进行长期动物研究。通过将撤回套管插入左心房和将返回套管插入降主动脉建立左心旁路。仅在插管时给予肝素抗凝，随后口服Warcantine，以保持凝血酶原时间为1.5 - 2.0倍。5只羊存活2周以上，最长存活46天。泵送过程中获得的泵流速为3.0至5.0 l/min。游离血红蛋白浓度低于20 mg/dl，与生化相关的其他参数在正常范围内。终止原因为插管血栓形成2只，全身感染1只，胃肠道紊乱1只，泵内血栓1只，这是存活时间最长的一只羊。这些结果表明，MSCP可以持续至少一个月以上，并且有希望应用于长期循环辅助装置，这是抢救严重心力衰竭患者所必需的。