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Study of a new treatment using excimer laser for severe ischemic heart disease

准分子激光治疗严重缺血性心脏病新疗法的研究

基本信息

批准号：
62480293
负责人：
BAN Toshihiko
金额：
$ 4.35万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480293/
关键词：
Excimer Laser XeCl Laser Angioplasty Laser Endarterectomy Ischemic Heart Disease Vaporization Thermal Injury Quartz Fiber エキシマレーザー塩化キセノンフッ化クリプトン血管形成術石英ファイバー KrF Xecl 心筋穿刺法

项目摘要

We studied the possible application of excimer laser to ischemic heart disease. In the first experiment, we studied the ablative effects of excimer laser at the wavelengths of 248 nm and 308 nm on the pig myocardium. Very clear cuts could be observed by histological examination, but there was a small adjacent line produced by thermal effect. A wavelength of 248 nm had less thermal effect than a wavelength of 308 nm. In addition we coupled the excimer laser to an optical fiber and measured the laser energy transmitted through the fiber. At a wavelength of 248 nm , the fibertip was destroyed. In the second experiment, we examined effects of excimer laser irradiation on blood. The lysis of erythrocytes does not occur in the laser - exposed cells. However, the damage to erythrocyte membrane took place as it was evidenced by progressive hemoglobin leakage into plasma. In the third experiment, we carried out a study on the possible application of the excimer laser in laser angioplasty. The healing responses following irradiation of the excimer laser to normal canine artery was satisfactory. Laser angioplasty was performed in 4 totally occluded femoral arteries in mongrel dogs using the excimer laser (XeCl : 308nm). The arteries were successfully recanalized in all 4 arteries using 2.5 - 6 m J/pulse, 20 - 30 pps and 6000 shots. Additionally, 4 WHHL rabbits were used in laser endarterectomy.Histological examination of all laser - irradiated arteries revealed favorable results with no signs of the thermal injury and no thrombus formation. The results suggest the applicability of excimer laser to ischemic heart disease.

我们研究了准分子激光治疗缺血性心脏病的可能性。在第一个实验中，我们研究了248 nm和308 nm准分子激光对猪心肌的消融作用。组织学检查可见非常清晰的切迹，但因热效应而产生一条较小的邻近线条。248 nm的热效应小于308 nm的热效应。此外，我们还将准分子激光器耦合到光纤上，并测量了通过光纤传输的激光能量。在248 nm的波长下，纤维尖端被破坏。在第二个实验中，我们检测了准分子激光照射对血液的影响。在激光照射的细胞中，红细胞没有发生溶解。然而，随着血红蛋白逐渐渗入血浆，红细胞膜发生了损伤。在第三个实验中，我们开展了准分子激光在激光血管成形术中的应用研究。准分子激光照射正常犬动脉后，愈合反应满意。采用准分子激光(XeCl308 Nm)对4条完全闭塞的杂种犬股动脉进行激光血管成形术。用2.5~6mJ/Pulse、20~30Pps、6000次/次的射程，4支动脉均成功再通。此外，4只WHHL兔用于激光动脉内膜剥脱术，所有激光照射的动脉的组织学检查结果良好，没有热损伤的迹象，也没有血栓形成。提示准分子激光治疗缺血性心脏病的可行性。