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Study for elevating effect of defibrillation threshold by antiarrythmic drugs during the treatment of arrythmia

抗心律失常药物治疗心律失常时提高除颤阈值的研究

基本信息

批准号：
05454414
负责人：
NAITO Hiroshi
金额：
$ 4.16万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

Abstract of 1st year : Many of the antiarrhythmic drugs produce a rise in the ventricular defibrillation threshold (DFT). Although mexiletine has also been reported as the probable cause of a significant elevation of DFT,there has been no previous study ; therefore, the effect of mexiletine on DFT was investigated in the present study. The experiments were performed on ten mongrel dogs. Mexiletine 1,2,4,6, or 8 mg/kg was administered as the loading dose, followed by the same dose/kg per hour. In these five groups, fibrillation/defibrillation (F/D) trials were performed repeatedly every 10 minutes, until 60 minutes after starting the maintenance dose. F/D trials were also performed at 30,45, and 60 minutes after the completion of mexiletine infusion. Applying internal paddles to the heart, energies of 2,3,5,7,10,20, and 30 J maximum were used. The mexiletine concentration in each group changed from 0 to 6.11 mug/ml, DFE ranged from 2-10 J,and no statistical correlation was found between mexiletine concentration and DFT.We conclude that mexiletine does not induce an increase in DFT in dogs.Abstract of 2nd year : The effect of mexiletine on DFT during continuous administration of flecainide was investigated in the 2nd year. The animals were prepared as same as 1st year. Flecainide 2 mg/kg was administered as the loading dose, followed by the same dose/kg per hour. Then, mexiletine 1,2,3,4,5 mg/kg was consecutively administered until the failure of defibrillation. F/D trials were performed in each phase. The minimal energy shock that caused defibrillation (DFT) increased according the increment dose of mexiletine. In conclusion, in a patient administered flecainide, we must be careful for administration of mexiletine in treating ventricular fibrillation.

第1年摘要：许多抗心律失常药物引起心室除颤阈值（DFT）升高。虽然mexileprazole也被报道为DFT显著升高的可能原因，但以前没有研究;因此，在本研究中研究了mexileprazole对DFT的影响。实验在10只杂种狗上进行。美西律1、2、4、6或8 mg/kg作为负荷剂量给药，随后以相同剂量/kg/h给药。在这五组中，每10分钟重复进行一次纤颤/除颤（F/D）试验，直至开始维持剂量后60分钟。在完成美西律输注后30、45和60分钟进行F/D试验。将内部桨应用于心脏，使用最大2、3、5、7、10、20和30 J的能量。各组中的美西律浓度从0变化到6.11 μ g/ml，DFE范围为2-10 J，并且在美西律浓度和DFT之间没有发现统计学相关性。我们得出结论，美西律不会引起犬DFT的增加。动物准备与第1年相同。氟卡尼2 mg/kg作为负荷剂量给药，随后以相同剂量/kg/h给药。然后连续给予美西律1、2、3、4、5 mg/kg，直至除颤失败。在每个阶段进行F/D试验。引起除颤的最小能量电击（DFT）随美西律剂量的增加而增加。总之，在使用氟卡尼的患者中，我们必须谨慎使用美西律治疗室颤。