Study for elevating effect of defibrillation threshold by antiarrythmic drugs during the treatment of arrythmia

抗心律失常药物治疗心律失常时提高除颤阈值的研究

基本信息

批准号：
05454414
负责人：
NAITO Hiroshi
金额：
$ 4.16万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

Abstract of 1st year : Many of the antiarrhythmic drugs produce a rise in the ventricular defibrillation threshold (DFT). Although mexiletine has also been reported as the probable cause of a significant elevation of DFT,there has been no previous study ; therefore, the effect of mexiletine on DFT was investigated in the present study. The experiments were performed on ten mongrel dogs. Mexiletine 1,2,4,6, or 8 mg/kg was administered as the loading dose, followed by the same dose/kg per hour. In these five groups, fibrillation/defibrillation (F/D) trials were performed repeatedly every 10 minutes, until 60 minutes after starting the maintenance dose. F/D trials were also performed at 30,45, and 60 minutes after the completion of mexiletine infusion. Applying internal paddles to the heart, energies of 2,3,5,7,10,20, and 30 J maximum were used. The mexiletine concentration in each group changed from 0 to 6.11 mug/ml, DFE ranged from 2-10 J,and no statistical correlation was found between mexiletine concentration and DFT.We conclude that mexiletine does not induce an increase in DFT in dogs.Abstract of 2nd year : The effect of mexiletine on DFT during continuous administration of flecainide was investigated in the 2nd year. The animals were prepared as same as 1st year. Flecainide 2 mg/kg was administered as the loading dose, followed by the same dose/kg per hour. Then, mexiletine 1,2,3,4,5 mg/kg was consecutively administered until the failure of defibrillation. F/D trials were performed in each phase. The minimal energy shock that caused defibrillation (DFT) increased according the increment dose of mexiletine. In conclusion, in a patient administered flecainide, we must be careful for administration of mexiletine in treating ventricular fibrillation.

第一年的摘要：许多抗心律失常药物会增加心室除颤阈值（DFT）。尽管墨西哥氨酸也被报道是DFT显着升高的可能原因，但以前没有研究。因此，在本研究中研究了墨西哥氨酸对DFT的影响。实验是对十只杂种犬进行的。墨西里1,2,4,6或8 mg/kg的剂量为加载剂量，其次是相同的剂量/kg。在这五组中，一次性/除颤（f/d）试验每10分钟反复进行一次，直到开始维持剂量后60分钟。 f/d试验也在30,45时进行，在墨西哥氨酸输注完成后60分钟。将内部桨涂在心脏上，使用2,3,5,7,10,20和30 J的能量。 The mexiletine concentration in each group changed from 0 to 6.11 mug/ml, DFE ranged from 2-10 J,and no statistical correlation was found between mexiletine concentration and DFT.We conclude that mexiletine does not induce an increase in DFT in dogs.Abstract of 2nd year : The effect of mexiletine on DFT during continuous administration of flecainide was investigated in the 2nd year.这些动物的制备与第一年一样。将氟卡尼2 mg/kg施用为加载剂量，然后每小时相同的剂量/kg。然后，连续施用甲米定为1,2,3,4,5 mg/kg，直到除颤失败。在每个阶段进行f/d试验。导致除颤（DFT）的最小能量冲击增加了墨西利赛的增量剂量。总之，在患者施用氟卡尼的患者中，我们必须小心地给药墨西甲胺以治疗心室纤颤。