The role of sympathetic nervous system in the genesis of pulmonary edema
交感神经系统在肺水肿发生中的作用
基本信息
- 批准号:05454420
- 负责人:
- 金额:$ 4.1万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1993
- 资助国家:日本
- 起止时间:1993 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We studied the role of sympathetic nervous system in the genesis of pulmonary edema. One of the purpose of this study was to determine the mechanism for neurogenic pulmonary edema, which is caused by massive sympathetic activation and has been demonstrated to be due to increased vascular permeability. We determined the effects of large doses of catecholamines on pulmonary vascular permeability. Epinephrine or norepinephrine (100,300 mug) was infused into isolated dog lungs perfused with heparinized blood at constant pressure. Both catecholamines increased the pulmonary capillary pressure but reduced the lung weights. The pulmonary vascular permeability, assessed by the capillary filtration coefficient (Kfc) and the isogravimetric capillary pressure, did not change significantly at 30 and 60 min after infusion of either catecholamine. These results suggest that large doses of catecholamines do not increase the pulmonary vascular permeability in isolated dog lungs. Indeed, the lung weigh … More t response to adrenaline contrasted with the responses to platelet-activating factor (PAF) and the stable thromboxane A_2 analogue (TxA_2). In lungs treated with PAF or TxA_2, capillary pressure similarly increased to the level equivalent to that in the adrenaline-treated lungs, but lung weight progressively increased. This comparison indicates that pulmonary vascular permeability of adrenaline-treated lungs is apparently smaller than that of lungs treated with either PAF or TxA_2, and may reinforce the conclusion that catecholamines do not increase pulmonary microvascular permeability. Another major purpose of this study was to determine whether activation of sympathetic nerve innervating lung causes an increase in pulmonary vascular permeability. No changes were found in pulmonary vascular permeability as evaluated by Kfc of either isolated canine or rabbit lungs, whose postganglionic fibers of stellate ganglions were electrically stimulated. These findings suggest that sympathetic nervous system may not play a crucial role in the integrity of pulmonary circulation. Less
我们研究了交感神经系统在肺水肿发生中的作用。本研究的目的之一是确定神经源性肺水肿的机制,神经源性肺水肿是由大量交感神经激活引起的,并已被证明是由于血管通透性增加。我们确定了大剂量的儿茶酚胺对肺血管通透性的影响。将肾上腺素或去甲肾上腺素(100,300 μ g)输注到在恒定压力下用肝素化血液灌注的离体狗肺中。这两种儿茶酚胺增加肺毛细血管压力,但减少肺重量。肺血管通透性,毛细血管滤过系数(Kfc)和等重毛细血管压力评估,并没有显着改变,在30和60分钟后输注的任一儿茶酚胺。这些结果表明,大剂量的儿茶酚胺并不增加肺血管通透性在离体狗肺。事实上, ...更多信息 对肾上腺素的反应与对血小板活化因子(PAF)和血栓素A_2类似物(TxA_2)的反应相反。PAF或TxA_2处理的肺,毛细血管压力也增加到与肾上腺素处理的肺相当的水平,但肺重量进行性增加。结果表明,肾上腺素处理的肺血管通透性明显小于PAF或TxA_2处理的肺血管通透性,从而进一步证实了儿茶酚胺不增加肺微血管通透性的结论。本研究的另一个主要目的是确定支配肺的交感神经的激活是否引起肺血管通透性的增加。肺血管通透性的KFC评价无论是离体犬或兔肺,其节后纤维的星状神经节电刺激没有发现变化。提示交感神经系统对肺循环的完整性可能不起决定性作用。少
项目成果
期刊论文数量(38)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Koyama,S.: "rBPI23 attenuates endotoxin-induced cardiovascular depression in awake rabbits." Shock. 4. 74-78 (1995)
Koyama,S.:“rBPI23 可以减轻清醒兔子中内毒素引起的心血管抑制。”
- DOI:
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- 影响因子:0
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Sawano,F.: "Baroreflex attenuation after hypotension induced by vena caval occlusion in anesthetized dogs." Am.J.Physiol.268. R859-R864 (1995)
Sawano, F.:“麻醉狗因腔静脉闭塞引起低血压后压力感受反射减弱。”
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- 影响因子:0
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Yamaguchi,Y.: "Hepatic vascular responese to anaphylaxis in isolated canine liver." Am.J.Physiol.267. R268-R274 (1994)
Yamaguchi,Y.:“离体犬肝脏中的肝血管对过敏反应的反应。”
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- 影响因子:0
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Shibamoto T.,Wang H-G.,et al.: "No effects of large doses of catecholamines on vascular permeability in isolated blood-perfused dog lungs." Acta. Physiol. Scand.155. 127-135 (1995)
Shibamoto T.、Wang H-G. 等人:“大剂量儿茶酚胺对离体血液灌注狗肺的血管通透性没有影响。”
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- 影响因子:0
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Matsuda, Y., Shibamoto, T.et al.: "Renal vascular and sympathetic nerve responses to hypotension induced by platelet-activating factor in anesthetized dogs." Eur. J.Pharmacol.250. 341-347 (1993)
Matsuda, Y., Shibamoto, T.等人:“肾血管和交感神经对麻醉狗血小板激活因子引起的低血压的反应。”
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- 影响因子:0
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SHIBAMOTO Toshishige其他文献
SHIBAMOTO Toshishige的其他文献
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{{ truncateString('SHIBAMOTO Toshishige', 18)}}的其他基金
Application of noninvasive thermography to detect the biphasic anaphylaxis in the rat
应用无创热成像检测大鼠双相过敏反应
- 批准号:
19K09445 - 财政年份:2019
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The role of angiopoietin-2 in anaphylactic shock
血管生成素2在过敏性休克中的作用
- 批准号:
16K11428 - 财政年份:2016
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Systematic study on brain circulation during anaphylactic shock
过敏性休克时脑循环的系统研究
- 批准号:
25462839 - 财政年份:2013
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Investigation on cardiac function during anaphylactic shock
过敏性休克时心功能的调查
- 批准号:
20592131 - 财政年份:2008
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Hepatic microvascular pressure during circulatory shock
循环休克期间的肝微血管压力
- 批准号:
18591730 - 财政年份:2006
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Integrative study on hepatic anaphylaxis
肝脏过敏反应的综合研究
- 批准号:
15591665 - 财政年份:2003
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Vascular occlusion methods analyze hepatic hemodynamics in acute and chronic liver injury
血管闭塞方法分析急慢性肝损伤中的肝脏血流动力学
- 批准号:
10557138 - 财政年份:1998
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The vascular occlusion methods for determination of hepatic vasoconstriction sites
血管闭塞法测定肝血管收缩部位
- 批准号:
08671723 - 财政年份:1996
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Involvement of Vagal and Sympathetic Afferents on Reflex Renal Nerve Responses to Bile into Canine Pancreatic Duct
迷走神经和交感神经传入对肾神经对胆汁进入犬胰管的反射反应的参与
- 批准号:
02807111 - 财政年份:1989
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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