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Involvement of Vagal and Sympathetic Afferents on Reflex Renal Nerve Responses to Bile into Canine Pancreatic Duct

迷走神经和交感神经传入对肾神经对胆汁进入犬胰管的反射反应的参与

基本信息

批准号：
02807111
负责人：
SHIBAMOTO Toshishige
金额：
$ 0.9万
依托单位：
Shinshu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

项目摘要

This study was designed to study effects of an injection of bile into the Pancreatic duct on mean blood pressure (MBP) and efferent renal nerve activity (RNA) in anesthetized dogs. When 0.5ml/kg of bile was injected into the pancreatic duct, RNA and MBP increased significantly. Peak changes of MBP and RNA were +26 <plus-minus> 8mmHg and +174 <plus-minus> 13%, respectively. When capsaicin (15ug/Kg) and bradykinin (20ug/Kg) were injected into the pancreatic duct, RNA increased significantly so that peak changes in RNA were +86<plus-minus> 11% and +72 <plus-minus> 12% of the control level, respectively. Injection of physiological saline did not cause any significant change in RNA and MBP. However, either after denervation of subdiaphragmatic vagal nerves or after celiac and superior mesenteric sympathectomy, the increase in RNA after injection of bile were significantly smaller than that in the intact animals. Contrastingly, the increased RNA due to capsaicin and bradykinin remained after subdiaphragmatic vagotomy, but disappeared after sympathectomy. In dogs with subdiaphragmatic vagotomy combined with celiac and superior mesenteric sympathectomy, RNA did not change significantly after bile injection. Therefore, these results suggest that injection of bile into the canine pancreatic duct evokes a reflex increase in RNA. which is mediated by both the vagal and sympathetic afferents from the pancreas. However, increases in RNA due to capsaicin and bradykinin are mediated only by sympathetic af

本研究旨在研究胰管内注射胆汁对麻醉犬平均血压(MBP)和肾传出神经活动(RNA)的影响。当胰管内注入0.5ml/kg胆汁时，RNA和MBP显著升高。MBP和RNA峰值变化分别为+26+-8 mm Hg和+174&lt；+-13%。胰管内注射辣椒素(15ug/kg)和缓激肽(20ug/kg)后，RNA显著增加，峰值分别为对照组的+86+-11%和+72+-12%。注射生理盐水后，RNA和MBP无明显变化。然而，无论是迷走神经切断后，还是腹腔和肠系膜上交感神经切除后，注射胆汁后RNA的增加均明显小于正常动物。相反，隔膜下迷走神经切断后辣椒素和缓激肽引起的RNA增加仍然存在，而交感神经切断后则消失。在横隔下迷走神经切断术联合腹腔和肠系膜上交感神经切断术的狗，注射胆汁后RNA没有明显变化。因此，这些结果表明，将胆汁注入犬胰管可引起RNA的反射性增加。这是由来自胰腺的迷走神经和交感神经传入调节的。然而，辣椒素和缓激肽引起的RNA增加仅由交感神经房颤介导。