Effects of dietary composition on colon carcinogenesis in the rats

在我们的研究结果中，饲喂乳糖饮食或普鲁兰饮食的大鼠表现出盲肠双歧杆菌增加，结肠黏膜鸟氨酸脱羧酶（ODC）活性降低，粪便中胆汁酸排泄减少。胃肠道中存在多种效应物，其中一些效应物可能作用于结肠，从而降低人类发生结肠癌的风险。盲肠内容物由多种成分组成，其中一些成分可能降低或促进致癌风险。它们的新陈代谢非常复杂，应该进行更详细的研究。综上所述，在饲喂乳糖日粮或普鲁兰日粮35周后，可以通过改变ODC的肠道菌群组成、粪胆汁酸和结肠黏膜活性来降低dmh处理大鼠的结肠癌发生率。需要进一步的研究来确定乳糖或普鲁兰的潜在保护作用。

In our results, rats fed the lactosucrose diet or pullulan diet demonstrated increases of Bifidobacterium in the cecum, a decrease of ornithine decarboxylase (ODC) activity in the colorectal mucosa, and a decrease of bile acid excretion into the feces. There are many kinds of effectors in the gastrointestinal tract, some of which might act on the colon to reduce the risk of colonc arcinogenesis in humans. The cecal contents are composed of various constituents, some of which may reduce or promote the risk carcinogenesis. Their metabolism is so complicated that it should be investigated in more detail.In conclusion, the intestinal microflora composition, fecal bile acid and colorectal mucosal activity of ODC can be modified to reduce the incidence of colon carcinogenesis in DMH-treated rats fed the lactosucrose diet or pullulan diet for 35 weeks. Further investigation is needed to define the potential protective effect of lactosucrose or pullulan.